Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study Katrina Abuabara, MD, MA, Ole Hoffstad, MS,

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Presentation transcript:

Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study Katrina Abuabara, MD, MA, Ole Hoffstad, MS, Andrea B. Troxel, ScD, Joel M. Gelfand, MD, MSCE, Charles E. McCulloch, PhD, David J. Margolis, MD, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 2, Pages 778-780.e6 (February 2018) DOI: 10.1016/j.jaci.2017.05.031 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Proportion of cohort reporting complete control without treatment by age and disease class. We plotted the proportion of individuals reporting complete control without treatment at each age for each of the 2 subgroups resulting from the latent class model using Epanechnikov kernel-weighted local polynomial smoothed plots with 95% CIs in gray. Note this graph represents actual data and not predicted probabilities from the models. Journal of Allergy and Clinical Immunology 2018 141, 778-780.e6DOI: (10.1016/j.jaci.2017.05.031) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Example of 4 individuals' response patterns of disease control by age. To illustrate how disease control varies over time, the response to the primary outcome measure, self-reported disease control with or without treatment, is shown on the y-axis, plotted against the age in years for 4 selected subjects. Rx, Prescription. Journal of Allergy and Clinical Immunology 2018 141, 778-780.e6DOI: (10.1016/j.jaci.2017.05.031) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Graphical comparison of results from 2 to 5 class models. Epanechnikov kernel-weighted local polynomial smoothed plots with 95% CIs in gray. The x-axis represents age in years, and y-axis represents the proportion of the cohort reporting complete control without treatment at each age. As more classes were added to the model, the “resolving” and “persistently active” subgroups, which included over 75% of the population, remained similar. Journal of Allergy and Clinical Immunology 2018 141, 778-780.e6DOI: (10.1016/j.jaci.2017.05.031) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions