Hematological phenotypes of hema6 mice.

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Hematological phenotypes of hema6 mice. Hematological phenotypes of hema6 mice. (A) RBCs exhibit spherocytosis when examined by Wright-Giemsa staining of blood smears. Image was taken at 40× magnification. (B) SEM highlighted the morphologic changes in the erythrocytes from hema6 mice. (C) Serum erythropoietin level. (D) Reticulocytes count. (E) Serum bilirubin level. (F) Shortened erythrocyte life span in hema6 mice. RBCs were labeled with biotin in vivo by injecting mice with biotinylation reagent N-hydroxysuccinimide-biotin at 6 wk of age. The survival of RBCs was followed by measurement of the percentage of labeled erythrocytes by FACS. In (C−F), measurements were done in mice at 8 wk of age, n = 3 for wild-type C57BL/6J control, n = 4 for hema6 homozygotes, data are expressed as mean ± SD. Asterisks denote the level of statistical significance (two-tailed Student’s t-test) between hema6 (−/−) and C57BL/6J mice. *P < 0.05; **P < 0.01; ***P < 0.001. To show the maximum difference between wild-type and hema6 mice, data on heterozygotes are not shown. (G) Splenic histology from C57BL/6J and hema6 homozygous mice. Spleens were isolated from wild-type or hema6 homozygotes and stained for hematoxylin and eosin. (H) High levels of iron deposition in hema6 (−/−) mice, assessed by Prussian blue staining of spleen sections. Hema6 mice have much more iron-positive cells (blue straining) relative to C57BL/6J controls. In both G and H, sections are shown at 10× magnification. Hua Huang et al. G3 2013;3:1687-1695 ©2013 by Genetics Society of America