Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune.

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Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. Immune cell populations, activation, and NKG2D and H60a expression in the spleen of untreated and antibiotic-treated Klrk1+/+ and Klrk1−/− NOD mice. (A) Percentage of total splenocytes in 12 wk old wild-type and Klrk1−/− NOD mice with or without antibiotic that were CD3− CD49b+ (NK cells), CD3− CD49b− (non-T or NK cells), or CD3+ (T cells). (B) Percentage of splenic T cells in (A) that were CD4+ and CD8+. (C) CD62L and CD44 expression by splenic CD4+ T cells in (A). (D) CD62L and CD44 expression by splenic CD8+ T cells in (A). (E–G) Percentage of splenic populations in (A) and (B) that expressed (E) CD69, (F) H60a, or (G) NKG2D. Data are combined results (mean ± SEM) of at least four mice per group. *p ≤ 0.05, **p ≤ 0.01 in two-tailed unpaired Mann–Whitney U test. Andrew P. Trembath et al. ImmunoHorizons 2017;1:198-212 Copyright © 2017 The Authors