ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cell Immunotherapy for High Risk Neuroblastomas and Sarcomas Haein Park, Aradhana Awasthi, Janet Ayello,

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ROR1-Specific Chimeric Antigen Receptor (CAR) NK Cell Immunotherapy for High Risk Neuroblastomas and Sarcomas Haein Park, Aradhana Awasthi, Janet Ayello, Yaya Chu, Stanley Riddell, Jeremy Rosenblum, Dean A. Lee, Mitchell S. Cairo Biology of Blood and Marrow Transplantation Volume 23, Issue 3, Pages S136-S137 (March 2017) DOI: 10.1016/j.bbmt.2017.01.056 Copyright © 2016 Terms and Conditions

Figure 1 NK cells significantly expanded by modified K562-mb.II.21-41BBL (A) and ROR1-CAR expression of ROR1-CAR aNK was significantly increased compared to Mock-aNK (B). Biology of Blood and Marrow Transplantation 2017 23, S136-S137DOI: (10.1016/j.bbmt.2017.01.056) Copyright © 2016 Terms and Conditions

Figure 2 ROR1-CAR-aNK cells had a specific cytotocixity against ROR1 positive Neuroblastoma (A) and Sarcoma cells (B) compared to ROR1 negative expressed cells in vitro (C). Biology of Blood and Marrow Transplantation 2017 23, S136-S137DOI: (10.1016/j.bbmt.2017.01.056) Copyright © 2016 Terms and Conditions