Antitumor effects of FF and gemcitabine on two pancreatic PDX models.

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Presentation transcript:

Antitumor effects of FF-10502 and gemcitabine on two pancreatic PDX models. Antitumor effects of FF-10502 and gemcitabine on two pancreatic PDX models. Patient-derived pancreatic cancer cells from PA5365 cells (A) and PA5364 cells (B) were mixed with Cultrex extracellular matrix and subcutaneously implanted into 10 NOD-SCID mice. When the average tumor size reached approximately 200 mm3, treatment with vehicle (saline), 240 mg/kg FF-10502, or 240 mg/kg gemcitabine was initiated and administered intravenously once weekly for 4 weeks. One-way analysis of variance and Tukey’s test were applied and significant differences are indicated; *P < 0.05; **P < 0.01; ***P < 0.005 between groups. Shinji Mima et al. J Pharmacol Exp Ther 2018;366:125-135 Copyright © 2018 The Author(s).