Ganghong Tian, MD, PhDa, Bo Xiang, DDSa, Keith W

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Presentation transcript:

A31P-Nuclear magnetic resonance study of intermittent warm blood cardioplegia Ganghong Tian, MD, PhDa, Bo Xiang, DDSa, Keith W. Butler, PhDa, Antonio M. Calafiore, MDb, Andrea Mezzetti, MDb, Tomás A. Salerno, MD, MScc, Roxanne Deslauriers, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 109, Issue 6, Pages 1155-1163 (June 1995) DOI: 10.1016/S0022-5223(95)70199-0 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Schematic representation of perfusion apparatus. Heart chamber, Shiley heater and bubble trap, and reservoirs are also connected to water bath for temperature control. 1, Heart; 2, heart chamber with nuclear magnetic resonance coil; 3, Shiley heater and air bubble trap; 4, roller pump; 5, reservoir; 6, oxygenator; 7, pressure transducer; O 2 blood, oxygenated blood; de-O 2 blood, deoxygenated blood. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Representative 31P-NMR spectra obtained during infusion of warm blood cardioplegia and subsequent interruptions. Observed phosphorus compounds include inorganic phosphate (Pi), phosphocreatine (PCr), and three peaks of ATP. Cardioplegic interruptions resulted in a significant decrease in phosphocreatine and increase in inorganic phosphate peaks. Recovery of phosphocreatine and inorganic phosphate levels occurred during subsequent cardioplegic perfusion. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 Time course of levels of myocardial ATP, phosphocreatine (PCr), and inorganic phosphate (Pi) from pig hearts during control perfusion, intermittent warm blood cardioplegia, and reperfusion. Data are presented as means plus or minus standard error of means. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Time course of levels of myocardial ATP, phosphocreatine (PCr), and inorganic phosphate (Pi) obtained from three groups of hearts throughout protocol. Data are presented as means plus or minus standard error of means. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Time course of levels of myocardial ATP, phosphocreatine (PCr), and inorganic phosphate (Pi) obtained from three groups of hearts throughout protocol. Data are presented as means plus or minus standard error of means. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 Time course of levels of myocardial ATP, phosphocreatine (PCr), and inorganic phosphate (Pi) obtained from three groups of hearts throughout protocol. Data are presented as means plus or minus standard error of means. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 Intracellular pH measured at the end of six 10-minute ischemic episodes. Data are presented as means plus or minus standard error of means (n = 9). The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 6 Comparison of rate-pressure product (RPP) and +dP/dt between pig hearts subjected to either continuous or intermittent warm blood cardioplegia or 150 minutes of control perfusion. The Journal of Thoracic and Cardiovascular Surgery 1995 109, 1155-1163DOI: (10.1016/S0022-5223(95)70199-0) Copyright © 1995 Mosby, Inc. Terms and Conditions