Mucosal flora in inflammatory bowel disease

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Presentation transcript:

Mucosal flora in inflammatory bowel disease Alexander Swidsinski, Axel Ladhoff, Annelie Pernthaler, Sonja Swidsinski, Vera Loening–Baucke, Marianne Ortner, Jutta Weber, Uwe Hoffmann, Stefan Schreiber, Manfred Dietel, Herbert Lochs Gastroenterology Volume 122, Issue 1, Pages 44-54 (January 2002) DOI: 10.1053/gast.2002.30294 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Percent of patients with high concentrations of mucosal bacteria. Gastroenterology 2002 122, 44-54DOI: (10.1053/gast.2002.30294) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 (A) Adenine sequences of 12 clones from a patient with a predominance of an E. coli sequence. (B) Adenine sequences from a patient with a mix of different bacterial sequences. Gastroenterology 2002 122, 44-54DOI: (10.1053/gast.2002.30294) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 FISH. Superficial bacterial layer (arrows) in unwashed and corresponding washed biopsies visualized with FISH using a universal probe. BL, basal lamina; G, goblet cell; N, nucleus. (A) CD patient with concentration of mucosal bacteria of 300 cfu/μL. (B) UC patient with concentration of mucosal bacteria of 1500 cfu/μL (B1) unwashed and (B2) washed. (C) CD patient with concentration of mucosal bacteria of 72,000 cfu/μL (C1) unwashed and (C2) washed. Gastroenterology 2002 122, 44-54DOI: (10.1053/gast.2002.30294) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 4 Intracellular bacteria (arrows) visualized with Bacteroides-specific probe. G, goblet cell; N, nucleus. Gastroenterology 2002 122, 44-54DOI: (10.1053/gast.2002.30294) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 5 Electron microscopic appearance of intraepithelial bacterial inclusions (arrows). (A-D) Concentrations of mucosal bacteria greater than 50,000 cfu/μL. (E) Concentration of mucosal bacteria of 19,000 cfu/μL. Bars = 1 μm. BL, basal lamina; er, endoplasmic reticulum; F, pericryptal fibroblast sheet; G, goblet cell; gr, mucous granules; M, mitochondria; N, nucleus; nu, nucleolus. Gastroenterology 2002 122, 44-54DOI: (10.1053/gast.2002.30294) Copyright © 2002 American Gastroenterological Association Terms and Conditions