Global vs Local Alignment

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Presentation transcript:

Global vs Local Alignment Jasmin sutkovic – Bioinformatics Lab 3 25.10.2018

What is the difference?

Global Alignment Compare the whole sequence, from one end to another, with our query sequence in order to find the best overall alignment

Local Alignment Compare only parts of the sequence with our query in order to get the best local alignments

Examples of Algorithms Global alignment: Needleman-Wunsch Local alignment: Smith-Waterman

Example

When do we use one and when the other?

Global Aligment When we want to compare the whole sequences or genes Usually when we are working with homologus genes

Local Alignment When we want to compare only parts of sequences or genes Usually when we are working with nonhomologus genes When we want to find the same/simillar protein domains in different genes

Thank you for your attenuation 