Pharmacokinetics of Gefitinib Predicts Antitumor Activity for Advanced Non-small Cell Lung Cancer Yoichi Nakamura, MD, PhD, Kazumi Sano, PhD, Hiroshi.

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Pharmacokinetics of Gefitinib Predicts Antitumor Activity for Advanced Non-small Cell Lung Cancer Yoichi Nakamura, MD, PhD, Kazumi Sano, PhD, Hiroshi Soda, MD, PhD, Hiroshi Takatani, MD, PhD, Minoru Fukuda, MD, PhD, Seiji Nagashima, MD, Tomayoshi Hayashi, MD, PhD, Mikio Oka, MD, PhD, Kazuhiro Tsukamoto, MD, PhD, Shigeru Kohno, MD, PhD Journal of Thoracic Oncology Volume 5, Issue 9, Pages 1404-1409 (September 2010) DOI: 10.1097/JTO.0b013e3181e59a7b Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Kaplan-Meier curves among all treated patients. A, Progression-free survival. B, Overall survival. ○: Censored case. Journal of Thoracic Oncology 2010 5, 1404-1409DOI: (10.1097/JTO.0b013e3181e59a7b) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A, Stratified by smoking status and D8/D3 ratio. B, Scattered plots demonstrate a positive correlation between the D8/D3 ratio and progression-free survival. C, Progression-free survival curves stratified by epidermal growth factor receptor mutations and D8/D3 ratio. Journal of Thoracic Oncology 2010 5, 1404-1409DOI: (10.1097/JTO.0b013e3181e59a7b) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions