Volume 4, Issue 4, Pages (May 2018)

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Volume 4, Issue 4, Pages 333-336 (May 2018) Dystrophic calcifications point the way—Unusual and early diagnostic clue of Conradi- Hünermann-Happle syndrome Kenneth Yu, MD, PhD, Alexander T. Reid, BA, Stephanie J.T. Chen, MD, Rajiv M. Patel, MD, Steven M. Donn, MD, Johann E. Gudjonsson, MD, PhD, Lori Lowe, MD JAAD Case Reports Volume 4, Issue 4, Pages 333-336 (May 2018) DOI: 10.1016/j.jdcr.2017.10.018 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Conradi-Hünermann-Happle syndrome with xerotic, featherlike, yellow-to-white hyperkeratotic scale distributed on the trunk and extremities. JAAD Case Reports 2018 4, 333-336DOI: (10.1016/j.jdcr.2017.10.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Conradi-Hünermann-Happle syndrome shows linear, erythematous, smooth, streaks in association with feathered hyperkeratotic scaly plaques on the left lower leg and dorsal foot. JAAD Case Reports 2018 4, 333-336DOI: (10.1016/j.jdcr.2017.10.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Conradi-Hünermann-Happle syndrome skin biopsy specimen shows hyperkeratosis with intracorneal calcifications (arrow) and dilated follicular ostia with keratotic plugging and calcification (arrowhead). (Hematoxylin-eosin stain; original magnification: ×100.) JAAD Case Reports 2018 4, 333-336DOI: (10.1016/j.jdcr.2017.10.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Conradi-Hünermann-Happle syndrome radiographic image shows stippled epiphyses on the proximal and distal right femur and at the ankle (arrows). JAAD Case Reports 2018 4, 333-336DOI: (10.1016/j.jdcr.2017.10.018) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions