The genetic susceptibility to IgA nephropathy: A novel functional candidate gene for incomplete O-glycosylation of IgA1 I. Narita, Y. Kaneko, D. Kondo,

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The genetic susceptibility to IgA nephropathy: A novel functional candidate gene for incomplete O-glycosylation of IgA1 I. Narita, Y. Kaneko, D. Kondo, S. Goto, M. Sakatsume, F. Gejyo Kidney International Volume 71, Issue 5, Pages 379-381 (March 2007) DOI: 10.1038/sj.ki.5002139 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Initiation of O-glycan biosynthesis.O-Glycosylation of protein is initiated by the addition of GalNAc to serine or threonine residues through the activity of UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases (pp-GalNAc-Ts), which is followed by β-galactosylation through core 1 synthase 1, also called glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1, core 1 β3-Gal-T, or T-synthase (C1GALT1). Kidney International 2007 71, 379-381DOI: (10.1038/sj.ki.5002139) Copyright © 2007 International Society of Nephrology Terms and Conditions