Assessment of joint space narrowing with conventional standing antero-posterior radiographs: relief in mild-to-moderate pain is not a confounder in recent osteoarthritis structure-modifying drug trials  L.C. Rovati, M.D., K. Pavelka, M.D., Ph.D., G. Giacovelli, Ph.D., J.-Y. Reginster, M.D., Ph.D.  Osteoarthritis and Cartilage  Volume 14, Pages 14-18 (January 2006) DOI: 10.1016/j.joca.2006.02.022 Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 Mean (SE) change in joint space width after 3 years in the global knee pain-improver subsets. Panel A reports the data pooled from both studies, while panels B and C show the data from the single studies of Reginster et al. and of Pavelka et al., respectively. N stands for the number of patients that qualified for the analysis in the placebo and glucosamine sulfate groups, respectively. Osteoarthritis and Cartilage 2006 14, 14-18DOI: (10.1016/j.joca.2006.02.022) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Mean (SE) change in joint space width after 3 years in the subset of patients with standing knee pain (item #5 in WOMAC pain scale) at least severe at baseline and improving by any degree after 3 years. Panel A reports the data pooled from both studies, while panels B and C show the data from the single studies of Reginster et al. and of Pavelka et al., respectively. N stands for the number of patients that qualified for the analysis in the placebo and glucosamine sulfate groups, respectively. Osteoarthritis and Cartilage 2006 14, 14-18DOI: (10.1016/j.joca.2006.02.022) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions