Apoptosis and necroptosis result in mitochondria dysfunction and injury. Apoptosis and necroptosis result in mitochondria dysfunction and injury. L929.

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Apoptosis and necroptosis result in mitochondria dysfunction and injury. Apoptosis and necroptosis result in mitochondria dysfunction and injury. L929 cells treated with STA (20 h) or TZS (6 h) were analyzed for loss of mitochondria membrane potential by costaining with MitoTracker Red and MitoTracker Green (A) or DiOC6 (B). Loss of red fluorescence intensity indicates depolarization. CCCP, a mitochondrial membrane depolarizing agent, was used as a positive control. (C) Superoxide production was measured with MitoSOX Red, producing a red fluorescence detectable by FACS. (D) mtDNA oxidation was determined by measuring the 8-OHdG content of DNA extracted from mitochondria of L929 cells treated with STA (20 h) or TZS (6 h). Comparisons were performed using a Kruskal–Wallis with Dunn multiple comparison test. A p value <0.05 was considered significant. Minghua Zhu et al. ImmunoHorizons 2018;2:384-397 Copyright © 2018 The Authors