Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy.

Slides:



Advertisements
Similar presentations
Chris H. J. Terhaard, M. D. , Ph. D. , Herman Lubsen, M. D. , Ph. D
Advertisements

External Beam Radiotherapy for Differentiated Thyroid Cancer
A Double-Blind Placebo-Controlled Randomized Clinical Trial With Magnesium Oxide to Reduce Intrafraction Prostate Motion for Prostate Cancer Radiotherapy 
John Boyle, MD, Brad Ackerson, MD, Lin Gu, MS, Chris R. Kelsey, MD 
Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From.
Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach  Miranda.
A predictive model for residual disease after (chemo) radiotherapy in oropharyngeal carcinoma: Combined radiological and clinical evaluation of tumor.
Catarina Dinis Fernandes, Cuong V. Dinh, Marcel J. Steggerda, Leon C
Procalcitonin to guide taking blood cultures in the intensive care unit; a cluster- randomized controlled trial  P.J. van der Geest, M. Mohseni, D. Nieboer,
Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma – Is PSMA-PET-CT a helpful tool in radiation oncology?  Laila König, Henrik.
Sexual quality of life following prostate intensity modulated radiation therapy (IMRT) with a rectal/prostate spacer: Secondary analysis of a phase 3.
Impact of magnetic resonance imaging on computed tomography-based treatment planning and acute toxicity for prostate cancer patients treated with intensity.
Alzheimer's disease drug development pipeline: 2018
RTOG 0631 phase 2/3 study of image guided stereotactic radiosurgery for localized (1- 3) spine metastases: Phase 2 results  Samuel Ryu, MD, Stephanie L.
SYSTEMS-2: A randomised phase II study of radiotherapy dose escalation for pain control in malignant pleural mesothelioma  M. Ashton, N. O'Rourke, N.
Evaluation of diffusion weighted imaging for tumor delineation in head-and-neck radiotherapy by comparison with automatically segmented 18F-fluorodeoxyglucose.
The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies  Richard Pötter,
Volume 12, Issue 2, Pages (February 2011)
Volume 151, Issue 1, Pages (October 2018)
Required target margins for image-guided lung SBRT: Assessment of target position intrafraction and correction residuals  Chirag Shah, MD, Larry L. Kestin,
Phase II Trial of Weekly Dose-Dense Paclitaxel in Extensive-Stage Small Cell Lung Cancer: Cancer and Leukemia Group B Study 39901  Stephen L. Graziano,
Hans Ligtenberg, Stefan M. Willems, Lilian N
Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma – Is PSMA-PET-CT a helpful tool in radiation oncology?  Laila König, Henrik.
Incorporating spatial dose metrics in machine learning-based normal tissue complication probability (NTCP) models of severe acute dysphagia resulting.
Esophageal Cancer Located at the Neck and Upper Thorax Treated with Concurrent Chemoradiation: A Single-Institution Experience  Shulian Wang, MD, Zhongxing.
Prophylactic Cranial Irradiation (PCI) versus Active MRI Surveillance for Small Cell Lung Cancer: The Case for Equipoise  Chad G. Rusthoven, MD, Brian.
PARADIGM-2: Two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed.
Prospective analysis of in vivo landmark point-based MRI geometric distortion in head and neck cancer patients scanned in immobilized radiation treatment.
Axillary radiotherapy for nodal lymphoma: What CTV expansion is required to account for absence of pre-chemotherapy treatment position FDG PET-CT?  Robin.
Potentials and challenges of diffusion-weighted magnetic resonance imaging in radiotherapy  Sara Leibfarth, René M. Winter, Heidi Lyng, Daniel Zips, Daniela.
Does motor block related to long-acting brachial plexus block cause patient dissatisfaction after minor wrist and hand surgery? A randomized observer-blinded.
Follow up results of a prospective study to evaluate the impact of FDG-PET on CT- based radiotherapy treatment planning for oesophageal cancer  Sweet Ping.
A neuropathic pain component as a predictor of improvement in pain interference after radiotherapy for painful tumors: A secondary analysis of a prospective.
Single dose partial breast irradiation using an MRI linear accelerator in the supine and prone treatment position  K.R. Charaghvandi, T. van't Westeinde,
A predictive model for residual disease after (chemo) radiotherapy in oropharyngeal carcinoma: Combined radiological and clinical evaluation of tumor.
Radiomic analysis in prediction of Human Papilloma Virus status
Age-not Charlson Co-morbidity Index-predicts for mortality after stereotactic ablative radiotherapy for medically inoperable stage I non-small cell lung.
Phase II study of induction chemotherapy with docetaxel, cisplatin, 5-fluorouracil followed by radioimmunotherapy with cetuximab and intensity-modulated.
Impact of waiting time on nodal staging in head and neck squamous-cell carcinoma treated with radical intensity modulated radiotherapy  Cédric Chevalier,
Study of diffusion weighted MRI as a predictive biomarker of response during radiotherapy for high and intermediate risk squamous cell cancer of the oropharynx:
A Phase II Study of Paclitaxel + Etoposide + Cisplatin + Concurrent Radiation Therapy for Previously Untreated Limited Stage Small Cell Lung Cancer (E2596):
Jean-Emmanuel Bibault, Ingeborg Tinhofer 
What is the impact of diabetes mellitus on radiation induced acute proctitis after radical radiotherapy for adenocarcinoma prostate? A prospective longitudinal.
PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor.
Clinical and radiobiological evaluation of a method for planning target volume generation dependent on organ-at-risk exclusions in magnetic resonance.
Prognostic impact of leukocyte counts before and during radiotherapy for oropharyngeal cancer  Garrett L. Jensen, Pierre Blanchard, G. Brandon Gunn, Adam.
Phase II Multicenter Trial with Carboplatin and Gemcitabine Induction Chemotherapy Followed by Radiotherapy Concomitantly with Low-Dose Paclitaxel and.
Catarina Dinis Fernandes, Cuong V. Dinh, Marcel J. Steggerda, Leon C
Clinical Trials of Adenovirus-mediated Therapy for Glioma
Whole-ventricular irradiation for intracranial germ cell tumors: Dosimetric comparison of pencil beam scanned protons, intensity-modulated radiotherapy.
Plasma proteins as prognostic biomarkers in radiotherapy treated head and neck cancer patients  Line Brøndum, Jesper Grau Eriksen, Brita Singers Sørensen,
An in-silico quality assurance study of contouring target volumes in thoracic tumors within a cooperative group setting  Hesham Elhalawani, Baher Elgohari,
Phase II Trial of Paclitaxel, Carboplatin, and Topotecan with G-CSF Support in Previously Untreated Patients with Extensive Stage Small Cell Lung Cancer:
Ending 40 years of silence: Rationale for a new staging system for soft tissue sarcoma of the head and neck  Ezra Hahn, Shao Hui Huang, Ali Hosni, Albiruni.
Clinical and Translational Radiation Oncology
Prostate-specific membrane antigen positron emission tomography/computed tomography as a potential tool to assess and guide salivary gland irradiation 
Patterns of practice in palliative radiotherapy for bleeding tumours in the Netherlands; a survey study among radiation oncologists  Jennifer Strijbos,
Stage I Non-small Cell Lung Cancer: Results for Surgery in a Patterns-of-Care Study in Sydney and for High-Dose Concurrent End-Phase Boost Accelerated.
Volume 124, Issue 1, Pages (January 2012)
Clinical implementation of magnetic resonance imaging guided adaptive radiotherapy for localized prostate cancer  Shyama U. Tetar, Anna M.E. Bruynzeel,
Target definition in radiotherapy of prostate cancer using magnetic resonance imaging only workflow  Adalsteinn Gunnlaugsson, Emilia Persson, Christian.
Clinical and Translational Radiation Oncology
A Collaborative Analysis of Stereotactic Lung Radiotherapy Outcomes for Early-Stage Non–Small-Cell Lung Cancer Using Daily Online Cone-Beam Computed Tomography.
R. Botman, S. U. Tetar, M. A. Palacios, B. J. Slotman, F. J
Clinical and Translational Radiation Oncology
A Randomized, Phase II Trial of Two Dose Levels of Temsirolimus (CCI-779) in Patients with Extensive-Stage Small-Cell Lung Cancer Who Have Responding.
Long-Term Follow-Up of a Phase I/II Trial of Dose Escalating Three-Dimensional Conformal Thoracic Radiation Therapy with Induction and Concurrent Carboplatin.
MRI basics for radiation oncologists
Prospective quantitative quality assurance and deformation estimation of MRI-CT image registration in simulation of head and neck radiotherapy patients 
Systematic review of methodology used in clinical studies evaluating the benefits of proton beam therapy  Mercy Ofuya, Lucy McParland, Louise Murray,
Presentation transcript:

Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR- ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial  Houda Bahig, Ying Yuan, Abdallah S.R. Mohamed, Kristy K. Brock, Sweet Ping Ng, Jihong Wang, Yao Ding, Kate Hutcheson, Molly McCulloch, Peter A. Balter, Stephen Y. Lai, Abrahim Al-Mamgani, Jan-Jakob Sonke, Uulke A. van der Heide, Christopher Nutting, X. Allen Li, Jared Robbins, Mussadiq Awan, Irene Karam, Katherine Newbold, Kevin Harrington, Uwe Oelfke, Shreerang Bhide, Marielle E.P. Philippens, Chris H.J. Terhaard, Andrew J. McPartlin, Pierre Blanchard, Adam S. Garden, David I. Rosenthal, Gary B. Gunn, Jack Phan, Guillaume Cazoulat, Michalis Aristophanous, Kelli K. McSpadden, John A. Garcia, Cornelis A.T. van den Berg, Cornelis P.J. Raaijmakers, Linda Kerkmeijer, Patricia Doornaert, Sanne Blinde, Steven J. Frank, Clifton D. Fuller  Clinical and Translational Radiation Oncology  Volume 13, Pages 19-23 (November 2018) DOI: 10.1016/j.ctro.2018.08.003 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Scheme of the 2-stage trial design. ECOG = Eastern Cooperative Oncology Group; MRgRT = Magnetic-Resonance guided radiotherapy; IMRT = Intensity Modulated Radiotherapy. Clinical and Translational Radiation Oncology 2018 13, 19-23DOI: (10.1016/j.ctro.2018.08.003) Copyright © 2018 The Authors Terms and Conditions