Donor Killer Immunoglobulin-Like Receptor Profile Bx1 Imparts a Negative Effect and Centromeric B-Specific Gene Motifs Render a Positive Effect on Standard-Risk.

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Donor Killer Immunoglobulin-Like Receptor Profile Bx1 Imparts a Negative Effect and Centromeric B-Specific Gene Motifs Render a Positive Effect on Standard-Risk Acute Myeloid Leukemia/Myelodysplastic Syndrome Patient Survival after Unrelated Donor Hematopoietic Stem Cell Transplantation Xiaojing Bao, Miao Wang, Huifen Zhou, Huanhuan Zhang, Xiaojin Wu, Xiaoni Yuan, Yang Li, Depei Wu, Jun He Biology of Blood and Marrow Transplantation Volume 22, Issue 2, Pages 232-239 (February 2016) DOI: 10.1016/j.bbmt.2015.09.007 Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Representation of Cen and Tel KIR gene motifs identified in a Chinese population from our previous family study [19]. One haplotype with unique Cen- and Tel- motifs was excluded because it was only observed in 1 family and the same profile was not detected in the present study. KIR2DS3/S5 was not included as a B-specific Cen-/Tel- gene because it can be located on either centromere or telomere part of the haplotype. Biology of Blood and Marrow Transplantation 2016 22, 232-239DOI: (10.1016/j.bbmt.2015.09.007) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) Effect of donor profile on OS and RFS after transplantation for AML/MDS patients (n = 122). Donor KIR profile Bx was associated with significant improved OS and RFS for AML patients. (B) Effect of donor profile on OS and RFS after transplantation for all patients (N = 210). The benefit of donor KIR profile Bx was not observed. Biology of Blood and Marrow Transplantation 2016 22, 232-239DOI: (10.1016/j.bbmt.2015.09.007) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 The effect of different KIR profiles on OS and RFS in AML/MDS patients (n = 122). Donor KIR profile Bx1 was a risk for decreased survival compared with AA (n = 65), Bx1 (n = 15), Bx2 (n = 12), Bx3 + Bx4 (n = 14), and other Bx (n = 16) donors. Biology of Blood and Marrow Transplantation 2016 22, 232-239DOI: (10.1016/j.bbmt.2015.09.007) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 The effect of different KIR profiles on OS and RFS in AML/MDS patients at standard risk. Donor KIR profile Bx1 (n = 8) was a risk for decreased survival compared with AA (n = 40), Bx2 (n = 11), and Bx3 + Bx4 (n = 11) donors. The OS and RFS of transplants from Bx1 donors was worse than that for AA donors. Biology of Blood and Marrow Transplantation 2016 22, 232-239DOI: (10.1016/j.bbmt.2015.09.007) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Impact of donor Cen-B on OS and RFS in AML/MDS patients at standard risk. Compared with donors without Cen-B (n = 61), donors with Cen-B (n = 21) were associated with improved OS and RFS in AML/MDS patients at standard risk. Biology of Blood and Marrow Transplantation 2016 22, 232-239DOI: (10.1016/j.bbmt.2015.09.007) Copyright © 2016 American Society for Blood and Marrow Transplantation Terms and Conditions