Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride  M. Meulyzer, D.V.M., P. Vachon, D.V.M., Ph.D., Dipl. A.C.L.A.M., F. Beaudry, Ph.D., T. Vinardell, D.V.M., H. Richard, G. Beauchamp, Ph.D., S. Laverty, M.V.B., M.R.C.V.S., Dipl. A.C.V.S., Dipl. E.C.V.S.  Osteoarthritis and Cartilage  Volume 17, Issue 2, Pages 228-234 (February 2009) DOI: 10.1016/j.joca.2008.06.018 Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 SF WBC count (A) and TP concentrations (B) in equine radiocarpal joints following IA injection of 0.125 or 0.5ng E. coli LPS (n=2 per group). Osteoarthritis and Cartilage 2009 17, 228-234DOI: (10.1016/j.joca.2008.06.018) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean (±s.e.m.) SF WBC count (A) and TP concentrations (B) in normal or inflamed radiocarpal joints of horses (n=8) following NG administration of 20mg/kg glucosamine hydrochloride or a placebo (arrow). Inflammation was induced 12h prior to NG intubation by IA injection of 0.25ng E. coli LPS. Osteoarthritis and Cartilage 2009 17, 228-234DOI: (10.1016/j.joca.2008.06.018) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Mean (±s.e.m.) plasma (A) and SF (B) glucosamine concentrations in horses (n=8) following NG administration of 20mg/kg glucosamine hydrochloride (arrow) in the presence or absence of synovial inflammation. Inflammation was induced 12h prior to glucosamine administration by IA injection of 0.25ng E. coli LPS in both radiocarpal joints. Osteoarthritis and Cartilage 2009 17, 228-234DOI: (10.1016/j.joca.2008.06.018) Copyright © 2008 Osteoarthritis Research Society International Terms and Conditions