Development of quantitative in vivo imaging of articular cartilage degradation in murine osteoarthritis P. Das Neves Borges, M.M. Fowkes, P.E. Brennan,

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Development of quantitative in vivo imaging of articular cartilage degradation in murine osteoarthritis P. Das Neves Borges, M.M. Fowkes, P.E. Brennan, T.L. Vincent, N.H. Lim Osteoarthritis and Cartilage Volume 25, Pages S33-S34 (April 2017) DOI: 10.1016/j.joca.2017.02.068 Copyright © 2017 Terms and Conditions

Fig. 1 3D imaging and quantification of articular cartilage degradation in the DMM model of murine osteoarthritis. A) Pseudo colour-coded map of X-ray absorption, expressed in Hounsfield units (HU), showing the tibial articular cartilage (blue-green range) imaged by DIPIC at 12-weeks post-DMM surgery. B) 3D automated segmentation and volumetric mapping (500 microns in width across 1 mm, colour-coded in light blue) for quantitative analysis of articular cartilage. C) Top view of a 3D model of the mouse tibia showing the location of the automated mappings. The red arrows indicate the presence of OA lesions in the articular cartilage. D) Bar graph of the percentage difference between articular cartilage volume in DMM-operated and contralateral in the medial and lateral aspects of the plateau at 4- and 12-weeks post-surgery (mean ± standard error the mean, n = 4).3 Osteoarthritis and Cartilage 2017 25, S33-S34DOI: (10.1016/j.joca.2017.02.068) Copyright © 2017 Terms and Conditions