Volume 56, Issue 4, Pages (October 1999)

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Volume 56, Issue 4, Pages 1299-1304 (October 1999) Cell survival or death in renal tubular epithelium after ischemia-reperfusion injury Glenda Gobé, Desley Willgoss, Nicole Hogg, Estelle Schoch, Zoltan Endre Kidney International Volume 56, Issue 4, Pages 1299-1304 (October 1999) DOI: 10.1046/j.1523-1755.1999.00701.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Comparison of body weights for treated and control animals at each experimental time point. No significant difference was found at each time point. Kidney International 1999 56, 1299-1304DOI: (10.1046/j.1523-1755.1999.00701.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Comparison of morphological assessment of levels of apoptosis (A) and counts for ISEL-positive nuclei (B). Kidney International 1999 56, 1299-1304DOI: (10.1046/j.1523-1755.1999.00701.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Apoptosis. Examples of (a) apoptotic cells in distal and proximal tubular epithelium are arrowed. (b and c) ISEL associated with apoptosis (examples arrowed in b) is compared with high, apparently nonapoptotic ISEL in the distal tubule at 24-hour post-IR (c). Kidney International 1999 56, 1299-1304DOI: (10.1046/j.1523-1755.1999.00701.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Cell proliferation. Numbers of PCNA-positive nuclei are compared after IR (a). Photomicrographs (b and c) demonstrate PCNA positive nuclei in controls (b; examples arrowed) and at 2 days post IR (c), where many darkly stained positive nuclei may be seen. Kidney International 1999 56, 1299-1304DOI: (10.1046/j.1523-1755.1999.00701.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 5 Schematic representation of a possible mechanism of cell death and survival in IR-induced ARF. Arrows indicate autocrine (A) or paracrine (P) movement of growth factors from the TAL (hatched) after protection by Bcl-2. The glomerulus (G) is indicated. Kidney International 1999 56, 1299-1304DOI: (10.1046/j.1523-1755.1999.00701.x) Copyright © 1999 International Society of Nephrology Terms and Conditions