Protective effect of vitamin C on 8-hydroxy-2′-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients Der-Cherng Tarng,

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Protective effect of vitamin C on 8-hydroxy-2′-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients Der-Cherng Tarng, Tsung-Yun Liu, Tung-Po Huang Kidney International Volume 66, Issue 2, Pages 820-831 (August 2004) DOI: 10.1111/j.1523-1755.2004.00809.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Spontaneous production of reactive oxygen species (ROS) in unstimulated lymphocytes before (□) and 8 weeks after treatment (▪). The percentages of increased in fluorescence above the resting level within 30 minutes are shown in all chronic hemodialysis patients, patients with ferritin values of <500 and ≥500 μg/L, and patients with transferrin saturation (TSAT) of <50 and ≥50%, respectively. Brackets indicate SD. aP < 0.05 vs. 0 week by Wilcoxon signed rank test. Kidney International 2004 66, 820-831DOI: (10.1111/j.1523-1755.2004.00809.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 Phorbol-12-myristate-13-acetate (PMA)-induced production of reactive oxygen species (ROS) in lymphocytes before (□) and 8 weeks after treatment (▪). The percentages of increased in fluorescence above the resting level within 30 minutes are shown in all chronic hemodialysis patients, patients with ferritin values of <500 and ≥500 μg/L, and patients with transferrin saturation (TSAT) of <50 and ≥50%, respectively. Brackets indicate SD. aP < 0.001; bP < 0.05 vs. 0 week by Wilcoxon signed rank test. Kidney International 2004 66, 820-831DOI: (10.1111/j.1523-1755.2004.00809.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 8-hydroxy-2′-deoxyguanosine (8-OHdG) contents in cellular DNA of peripheral blood lymphocytes before (□) and 8 weeks after treatment (▪) in all chronic hemodialysis patients, patients with ferritin values of <500 and ≥500 μg/L, and patients with transferrin saturation (TSAT) of <50 and ≥50%, respectively.aP < 0.01; bP < 0.05 vs. 0 week by Wilcoxon signed rank test. Kidney International 2004 66, 820-831DOI: (10.1111/j.1523-1755.2004.00809.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Steady-state hOGG1 and hMTH1 mRNA levels analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) in peripheral blood lymphocytes. Abbreviations are: M, marker; N, normal healthy controls; U, uremic patients not receiving dialysis yet; and H, hemodialysis patients. Quantitated data were expressed as the proportion of the specific gene product to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) product for expression of hOGG1 (A) and hMTH1 (B), respectively. Brackets indicate SD. aP < 0.05 vs. normal controls; bP < 0.05 vs. undialyzed patients. Kidney International 2004 66, 820-831DOI: (10.1111/j.1523-1755.2004.00809.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 5 Expression of hOGG1 and hMTH1 mRNAs analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) in peripheral blood lymphocytes of chronic hemodialysis patients with ferritin values of <500 and ≥500 μg/L at 24 hours of vitamin C or placebo investigated. Abbreviations are: M, marker; B, baselines; C, vitamin C treatment; and P, placebo. Quantitated data were expressed as the proportion of the specific gene product to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) product for expression of hOGG1 (A) and hMTH1 (B), respectively. Brackets indicate SD. aP < 0.05 vs. baselines; bP < 0.05 vs. placebo. Kidney International 2004 66, 820-831DOI: (10.1111/j.1523-1755.2004.00809.x) Copyright © 2004 International Society of Nephrology Terms and Conditions