Nandita M. deSouza, Veronica A. Morgan, Elizabeth Bancroft, S

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Diffusion-weighted MRI for detecting prostate tumour in men at increased genetic risk Nandita M. deSouza, Veronica A. Morgan, Elizabeth Bancroft, S. Aslam Sohaib, Sharon L. Giles, Zsofia Kote-Jarai, Elena Castro, Steven Hazell, Maysam Jafar, Rosalind Eeles European Journal of Radiology Open Volume 1, Pages 22-27 (January 2014) DOI: 10.1016/j.ejro.2014.08.002 Copyright © 2014 The Authors Terms and Conditions

Fig. 1 STARD flow chart for index test (endorectal diffusion-weighted MRI at 3.0T) for detecting tumour by observer 1 and observer 2 against a standard 10-core random sampling transrectal ultrasound biopsy technique in men with a family history of prostate cancer stratified by genetic risk. European Journal of Radiology Open 2014 1, 22-27DOI: (10.1016/j.ejro.2014.08.002) Copyright © 2014 The Authors Terms and Conditions

Fig. 2 True positive for prostate cancer in a 58 year old man: transverse T2-W images (FSE 2500/80ms [TR/TE]) images (A) through the mid prostate obtained with an endorectal coil at 3.0T and corresponding ADC maps (B) generated from a monoexponential fit of diffusion-weighted data (EPI 8000/69ms [TR/TE], b=0, 100, 800mm2/s). Outlines for whole prostate and central gland are given on the ADC maps. A lesion is not visible on the T2-W images, but a focally restricted area on the ADC maps (arrow) corresponded to a positive biopsy from that sextant. European Journal of Radiology Open 2014 1, 22-27DOI: (10.1016/j.ejro.2014.08.002) Copyright © 2014 The Authors Terms and Conditions

Fig. 3 False positive for prostate cancer in a 46 year old man: transverse T2-W images (FSE 2500/80ms [TR/TE]) images (A) through the mid prostate obtained with an endorectal coil at 3.0T and corresponding ADC maps (B) generated from a monoexponential fit of diffusion-weighted data (EPI 8000/69ms [TR/TE], b=0, 100, 800mm2/s). Outlines for whole prostate and central gland are given on the ADC maps. Although a lesion is not visible on the T2-W image, a small focally restricted area on the ADC maps (arrow) was seen medially. However, all 12 biopsies from this subject were negative for tumour. European Journal of Radiology Open 2014 1, 22-27DOI: (10.1016/j.ejro.2014.08.002) Copyright © 2014 The Authors Terms and Conditions