Dendritic cells and innate immunity in kidney transplantation

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Presentation transcript:

Dendritic cells and innate immunity in kidney transplantation Quan Zhuang, Fadi G. Lakkis Kidney International Volume 87, Issue 4, Pages 712-718 (April 2015) DOI: 10.1038/ki.2014.430 Copyright © 2015 International Society of Nephrology Terms and Conditions

Figure 1 Innate allorecognition and danger link innate to adaptive immunity after transplantation. Recognition of allogeneic non-self by recipient monocytes is key for generating mature DCs that drive graft rejection by T lymphocytes. Danger, which causes inflammation in the graft but is not sufficient for driving rejection, is nevertheless essential for potentiating the adaptive alloimmune response. Kidney International 2015 87, 712-718DOI: (10.1038/ki.2014.430) Copyright © 2015 International Society of Nephrology Terms and Conditions