Frances Balkwill, Kellie A. Charles, Alberto Mantovani Cancer Cell

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence Carmen Guerra, Manuel Collado, Carolina Navas,

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells Nilay Sethi, Xudong Dai, Christopher.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics Carlos L. Arteaga, Jeffrey A. Engelman Cancer Cell Volume.

Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia Tim C.P. Somervaille, Michael L. Cleary Cancer Cell.

Modeling Inducible Human Tissue Neoplasia Identifies an Extracellular Matrix Interaction Network Involved in Cancer Progression Jason A. Reuter, Susana.

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung Zvi Granot, Erik Henke, Elizabeth A. Comen, Tari A. King, Larry Norton, Robert Benezra.

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

A Conditional Mouse Model for Malignant Mesothelioma Johan Jongsma, Erwin van Montfort, Marc Vooijs, John Zevenhoven, Paul Krimpenfort, Martin van der.

Gastrulation Movements: the Logic and the Nuts and Bolts Maria Leptin Developmental Cell Volume 8, Issue 3, Pages (March 2005) DOI: /j.devcel

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

The Kinase-Independent, Second Life of CDK6 in Transcription

Charles Swanton, Julian Downward Cancer Cell

Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg

Settling a Nervous Stomach: The Neural Regulation of Enteric Cancer

CD5: A New Partner for IL-6

Adrienne D. Cox, Kenneth P. Olive Cancer Cell

Intravascular Survival and Extravasation of Tumor Cells

Metastasis gets site specific

Alan N. Houghton, Hiroshi Uchi, Jedd D. Wolchok Cancer Cell

HSF1 in Translation Cancer Cell

RAS unplugged: Negative feedback and oncogene-induced senescence

Some DCs Are “B”etter Immunity

Andrew G. Muntean, Jay L. Hess Cancer Cell

Killing Tumors by Keeping Ras and PI3′ Kinase Apart

Cell signaling and cancer

Therapeutic targeting of the tumor microenvironment

MSCs, Macrophages, and Cancer: A Dangerous Ménage-à-Trois

DAISY: Picking Synthetic Lethals from Cancer Genomes

Deregulating EMT and Senescence: Double Impact by a Single Twist

Volume 26, Issue 1, Pages 1-2 (July 2014)

Macrophage Metabolism Shapes Angiogenesis in Tumors

ABT-199: Taking Dead Aim at BCL-2

A Radical Role for p38 MAPK in Tumor Initiation

The AML Salad Bowl Cancer Cell

Macrophages and Therapeutic Resistance in Cancer

Is Predisposition to NAFLD and Obesity Communicable?

Macrophages and Therapeutic Resistance in Cancer

Hopping between Differentiation States in Lung Adenocarcinoma

Ning Li, Sergei I. Grivennikov, Michael Karin Cancer Cell

Volume 36, Issue 1, Pages 2-14 (October 2009)

Volume 6, Issue 3, Pages (September 2004)

Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian Cell Stem Cell

Deregulating EMT and Senescence: Double Impact by a Single Twist

Inflammation Joins the “Niche”

Tumor Promotion via Injury- and Death-Induced Inflammation

Neutrophils, Wounds, and Cancer Progression

Tumor-Associated Macrophages: From Mechanisms to Therapy

LKB1 and Src: Antagonistic Regulators of Tumor Growth and Metastasis

Copyright © 2013 Elsevier Inc. All rights reserved.

NO Signals from the Cancer Stem Cell Niche

Polarization of Tumor-Associated Macrophages: A Novel Strategy for Vascular Normalization and Antitumor Immunity Yuhui Huang, Matija Snuderl, Rakesh.

Sterile Inflammation Fuels Gastric Cancer

Pregnancy and breast cancer: The other side of the coin

To Infinium, and Beyond! Cancer Cell

Volume 10, Issue 3, Pages (September 2006)

Co-opted integrin signaling in ErbB2-induced mammary tumor progression

Immune Cells Exploit a Neural Circuit to Enter the CNS

Some DCs Are “B”etter Immunity

Macrophage Metabolism Shapes Angiogenesis in Tumors

There's a Time and a Place for MYCN

Volume 17, Issue 2, Pages (February 2010)

Ibrutinib Treatment of CLL: The Cancer Fights Back

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

The AML Salad Bowl Cancer Cell

Presentation transcript:

Smoldering and polarized inflammation in the initiation and promotion of malignant disease Frances Balkwill, Kellie A. Charles, Alberto Mantovani Cancer Cell Volume 7, Issue 3, Pages 211-217 (March 2005) DOI: 10.1016/j.ccr.2005.02.013 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Type II macrophages in the tumor microenvironment. Mononuclear phagocytes recruited in chimeras polarize in an M2 direction in response to microenvironmental signals. M2 TAMs promote chimera progression, matrix remodeling, and angiogenesis, and divert and tame adaptive immunity. Cancer Cell 2005 7, 211-217DOI: (10.1016/j.ccr.2005.02.013) Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 2 Mechanisms of inflammation-induced cancer Wide blue arrows indicate the primary source of the inflammatory stimulus. Cancer Cell 2005 7, 211-217DOI: (10.1016/j.ccr.2005.02.013) Copyright © 2005 Elsevier Inc. Terms and Conditions