Functional prediction of unknown proteins in S. pneumoniae.

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Functional prediction of unknown proteins in S. pneumoniae. Functional prediction of unknown proteins in S. pneumoniae. Augmenting the network of protein interactions of S. pneumoniae with interactions of other bacteria, we predicted the functions of 299 proteins with unknown or poorly characterized functions (FDR = <0.05). We annotated each protein with the difference in the s-index value, deducting the corresponding value in the original network of interactions in S. pneumoniae and the value in the augmented network. For example, SP_1876 had a 66% chance (FDR = <0.05) of being involved in transcriptional activities. Scores for each protein and the corresponding functional prediction are provided in Table S4. S. Wuchty et al. mSystems 2017; doi:10.1128/mSystems.00019-17