Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty- seven cases Hidefumi Takei, MDa,b, Hisao Asamura, MDb, Arafumi Maeshima,

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Large cell neuroendocrine carcinoma of the lung: A clinicopathologic study of eighty- seven cases Hidefumi Takei, MDa,b, Hisao Asamura, MDb, Arafumi Maeshima, MDc, Kenji Suzuki, MDb, Haruhiko Kondo, MDb, Toshiro Niki, MDc, Tesshi Yamada, MDc, Ryosuke Tsuchiya, MDa,b, Yoshihiro Matsuno, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 2, Pages 285-292 (August 2002) DOI: 10.1067/mtc.2002.122523 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 A, Representative photomicrograph of LCNEC. Organoid pattern, palisading, and necrosis are shown. (Hematoxylin and eosin; original magnification 100×.) B, Tumor cells are large and polygonal with abundant and finely granular cytoplasm, easily discernible nucleoli in some cells. Note also rosette-like structures. (Hematoxylin and eosin; original magnification 400×.) The Journal of Thoracic and Cardiovascular Surgery 2002 124, 285-292DOI: (10.1067/mtc.2002.122523) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Representative staining of chromogranin A in LCNEC cases: A, Focal; B, patchy; C, diffuse. (Immunostain; original magnification 400×.) The Journal of Thoracic and Cardiovascular Surgery 2002 124, 285-292DOI: (10.1067/mtc.2002.122523) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Survival curves of patients with LCNEC (n = 87), other poorly differentiated NSCLCs (n = 426), LCC (n = 102), and SCLC (n = 31) for all stages. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 285-292DOI: (10.1067/mtc.2002.122523) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Survival curves of 41 patients with LCNEC of stage I and 126 patients with other poorly differentiated NSCLCs of stage I (P =.003, log-rank test). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 285-292DOI: (10.1067/mtc.2002.122523) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Survival curves of 41 patients with LCNEC of stage I and 29 patients of LCC of stage I (P =.03, log-rank test). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 285-292DOI: (10.1067/mtc.2002.122523) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Survival curves of 41 patients with LCNEC of stage I and 9 patients with SCLC of stage I (P =.87, log-rank test). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 285-292DOI: (10.1067/mtc.2002.122523) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions