Eszter Ducza, Ph. D. , Róbert Gáspár, Ph. D. , Attila Mihályi, Ph. D

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The roles of the α1-adrenergic receptor subtypes in rat embryonic implantation Eszter Ducza, Ph.D., Róbert Gáspár, Ph.D., Attila Mihályi, Ph.D., Zsolt Kormányos, Ph.D., George Falkay, Ph.D., D.Sc. Fertility and Sterility Volume 91, Issue 4, Pages 1224-1229 (April 2009) DOI: 10.1016/j.fertnstert.2008.01.081 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 The changes in messenger RNA (mRNA) expression (A) and the protein level (B) of α1A-AR in the nonpregnant and the early-pregnant rat uterus, measured by reverse transcription–polymerase chain reaction (RT-PCR) and Western blot, as described in the Materials and Methods section. (not significant = P>.05; ∗P<.05; ∗∗∗P<.001 compared with the data on the previous day). Each bar represents the mean ± SD, n = 6. Fertility and Sterility 2009 91, 1224-1229DOI: (10.1016/j.fertnstert.2008.01.081) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Inhibitory effects of the α1A-antagonist 5-methylurapidil (5-MU) on electric field-stimulated contractions on different days of early pregnancy in the isolated rat uterus in vitro. The EC50 (concentration of terbutaline eliciting 50% of the maximal [100%] inhibition of uterine contractions) values were significantly shifted on days 5 and 6; the maximal inhibitory effect was increased on day 5, and remained unchanged up to day 7. Fertility and Sterility 2009 91, 1224-1229DOI: (10.1016/j.fertnstert.2008.01.081) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 3 The changes in α1A-AR messenger RNA (mRNA) expression after α1A-AR antisense oligodeoxynucleotide treatment in the rat myometrium, measured by reverse transcription–polymerase chain reaction as described in the Materials and Methods section. The relative amounts of the receptor subtype mRNAs are indicated by the optical densities of the bands (not significant = P>.05; ∗P<.05 compared with the data on the previous day). Each bar represents the mean ± SD, n = 6. Fertility and Sterility 2009 91, 1224-1229DOI: (10.1016/j.fertnstert.2008.01.081) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 4 The effect of α1A-AR antisense oligodeoxynucleotide (AON) on implantation in rats (A). The absence of implantation sites (arrows) (B) in the AON-treated rat uteri and the presence in the control uteri (C) were seen on day 10. Fertility and Sterility 2009 91, 1224-1229DOI: (10.1016/j.fertnstert.2008.01.081) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions