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Volume 15, Issue 6, Pages 631-639 (May 2014) Intermittent chemotherapy plus either intermittent or continuous cetuximab for first-line treatment of patients with KRAS wild-type advanced colorectal cancer (COIN-B): a randomised phase 2 trial Harpreet Wasan, MD, Dr Angela M Meade, DPhil, Richard Adams, MD, Richard Wilson, MD, Cheryl Pugh, BSc, David Fisher, MSc, Benjamin Sydes, Ayman Madi, MD, Bruce Sizer, MB, Charles Lowdell, FRCP, Gary Middleton, MD, Rachel Butler, BSc, Prof Richard Kaplan, MD, Prof Tim Maughan, MD The Lancet Oncology Volume 15, Issue 6, Pages 631-639 (May 2014) DOI: 10.1016/S1470-2045(14)70106-8 Copyright © 2014 Wasan et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial design Treatment cycles continued until progressive disease (PD) with maximally tolerated treatment, or patient choice. FOLFOX=folinic acid and oxaliplatin followed by bolus and infused fluorouracil. The Lancet Oncology 2014 15, 631-639DOI: (10.1016/S1470-2045(14)70106-8) Copyright © 2014 Wasan et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Trial profile The Lancet Oncology 2014 15, 631-639DOI: (10.1016/S1470-2045(14)70106-8) Copyright © 2014 Wasan et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Kaplan-Meier analyses of failure-free survival The Lancet Oncology 2014 15, 631-639DOI: (10.1016/S1470-2045(14)70106-8) Copyright © 2014 Wasan et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Kaplan-Meier analyses of overall survival The Lancet Oncology 2014 15, 631-639DOI: (10.1016/S1470-2045(14)70106-8) Copyright © 2014 Wasan et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 5 Kaplan-Meier analyses of progression-free survival during the chemotherapy-free interval The Lancet Oncology 2014 15, 631-639DOI: (10.1016/S1470-2045(14)70106-8) Copyright © 2014 Wasan et al. Open Access article distributed under the terms of CC BY Terms and Conditions