Alterations related to androgen signaling.

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Alterations related to androgen signaling. Alterations related to androgen signaling. A, illustration of the AR full-length (FL) gene, including exons 1–8, and AR transcript variant 7 (V7), including exons 1–3 and cryptic exon 3 (CE3). B, Sashimi plots showing RNA-Seq reads that span more than one AR exon. Representative cases with (top) or without (bottom) reads spanning exon 3 and CE3 are shown. C, quantification of AR-FL and AR-V7 expression based on RNA-Seq (top), and RT-PCR using cDNA extracted from tumor RNA (bottom). D, correlation between AR and FOXA1 expression. P < 0.0001, two-tailed Pearson correlation test. E, location of SDC mutations within the FOXA1 gene. Previously reported mutations were acquired from the cBioPortal database (cbioportal.org) and represents cases from any cancer. TA, transactivation domain; forkhead N, forkhead N-terminal domain. F, correlation between AR IHC (red, positive; blue, negative), AR expression (based on z-score), and AR signaling index (see Materials and Methods) with FOXA1 mutation status. G, correlation between AR expression and AR signaling index. P, one-tailed Spearman correlation. Martin G. Dalin et al. Clin Cancer Res 2016;22:4623-4633 ©2016 by American Association for Cancer Research