TUCAN (CARD8) Genetic Variants and Inflammatory Bowel Disease Dermot P.B. McGovern, Helen Butler, Tariq Ahmad, Marta Paolucci, David A. van Heel, Kenichi Negoro, Pirro Hysi, Jiannis Ragoussis, Simon P.L. Travis, Lon R. Cardon, Derek P. Jewell  Gastroenterology  Volume 131, Issue 4, Pages 1190-1196 (October 2006) DOI: 10.1053/j.gastro.2006.08.008 Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

Figure 1 Cartoon showing linkage disequilibrium pattern across TUCAN (created in Haploview). Values represent 100 × D′ values of linkage disequilibrium. The blank squares represent D′ values of 1.0. Three haplotypes are marked as predicted by Haploview (see Materials and Methods). Gastroenterology 2006 131, 1190-1196DOI: (10.1053/j.gastro.2006.08.008) Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions

Figure 2 Adaptation of Fagan’s nomogram29 showing the approximate relationship between pretest probabilities, likelihood ratios, and posttest probabilities. Pretest probabilities are estimated from the clinical picture or from population prevalence data. In this example, the pretest probabilities of 30%, 50% (see discussion), and 0.2% (approximate population prevalence of CD) have been chosen to illustrate the clinical utility of likelihood ratios. The nomogram shows how a positive likelihood ratio of approximately 8 (Table 4) can “convert” the pretest probabilities of 30%, 50%, and 0.2% to posttest probabilities of approximately 75%, 90%, and 1.7%, respectively. Similarly, a negative likelihood ratio of 0.2 converts pretest probabilities of 30% and 50% to posttest probabilities of approximately 8% and 17%. Gastroenterology 2006 131, 1190-1196DOI: (10.1053/j.gastro.2006.08.008) Copyright © 2006 American Gastroenterological Association (AGA) Institute Terms and Conditions