a) Secondary binding data for ivacaftor

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Presentation transcript:

a) Secondary binding data for ivacaftor a) Secondary binding data for ivacaftor. [3H]mesulergine displacement data (Ki=866 nM) binding to the 5-hydroxytryptamine (5-HT; serotonin) 5-HT2C receptor. a) Secondary binding data for ivacaftor. [3H]mesulergine displacement data (Ki=866 nM) binding to the 5-hydroxytryptamine (5-HT; serotonin) 5-HT2C receptor. The reference compound is ritanserin (Ki=0.57 nM). b) Secondary binding data for ivacaftorcarboxylate (iva-M6). [3H]ketanserin displacement data (Ki=147 nM) binding to the 5-HT2A receptor. The reference compound is clozapine (Ki=2.4 nM). CPM: counts per minute. Elena K. Schneider et al. ERJ Open Res 2018;4:00127-2017 ©2018 by European Respiratory Society