Eosinophilic Granuloma of the Lung JAMES W. QUINN, M.D., PHILIP C. PRATT, M.D.  Diseases of the Chest  Volume 38, Issue 2, Pages 205-210 (August 1960) DOI: 10.1378/chest.38.2.205 Copyright © 1960 The American College of Chest Physicians Terms and Conditions

FIGURE 1 Case 1. Chest roentgenogram showing the typical bilateral nodular infiltrate of eosinophilic granuloma with areas of emphysema and fibrosis. Diseases of the Chest 1960 38, 205-210DOI: (10.1378/chest.38.2.205) Copyright © 1960 The American College of Chest Physicians Terms and Conditions

FIGURE 2 Case 1. Portion of a nodule of eosinophilic granuloma. The figure reveals almost complete obliteration of pulmonary architecture with only a few alveolar spaces recognizable. In the area of obliteration, alveolar septa and lumen are infiltrated with innumerable cells of essentially two types: macrophages and eosinophiles. The macrophages, or histiocytes, are seen as large poorly demarcated cells with much cytoplasm and with pale round or oval nuclei. The smaller denser cells intervening between the macrophages are eosinophiles. (100 X) Diseases of the Chest 1960 38, 205-210DOI: (10.1378/chest.38.2.205) Copyright © 1960 The American College of Chest Physicians Terms and Conditions

FIGURE 3 Chest roentgenogram of case of Loeffler’s syndrome (proven by biopsy), showing patchy pneumonic infiltrate. Diseases of the Chest 1960 38, 205-210DOI: (10.1378/chest.38.2.205) Copyright © 1960 The American College of Chest Physicians Terms and Conditions

FIGURE 4 Loeffler’s syndrome (Buckles3). The area illustrated contains a zone of pneumonic consolidation consisting almost entirely of small cells with dense nuclei which are eosinophiles although the granules are not recognizable at this magnification. At the top center and lower right are small areas of granulomatous inflammation with infiltrating macrophages and scattered eosinophiles. (100 X) Diseases of the Chest 1960 38, 205-210DOI: (10.1378/chest.38.2.205) Copyright © 1960 The American College of Chest Physicians Terms and Conditions

FIGURE 5 Loeffler’s syndrome, acute stage. The figure shows a large area of pneumonic consolidation by small cells with dense nuclei virtually all of which are eosinophiles. Note also a moderate perivascular adventitial infiltration by eosinophiles. (100 X) Diseases of the Chest 1960 38, 205-210DOI: (10.1378/chest.38.2.205) Copyright © 1960 The American College of Chest Physicians Terms and Conditions

FIGURE 6 Loeffler’s syndrome, late stage. In this case pneumonic consolidation has completely disappeared but there is thickening and infiltration of alveolar septa and perivascular areas by small cells with dense nuclei, eosinophiles. Among the eosinophiles are scattered larger infiltrating macrophages or histiocytes. The resemblance betwen this appearance and that characteristic of eosinophilic granuloma is apparent. (100 X) Diseases of the Chest 1960 38, 205-210DOI: (10.1378/chest.38.2.205) Copyright © 1960 The American College of Chest Physicians Terms and Conditions