Michael A. Ricci, MD, Gail Strindberg, MD, Jeffery M

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Anti-CD 18 monoclonal antibody slows experimental aortic aneurysm expansion Michael A. Ricci, MD, Gail Strindberg, MD, Jeffery M. Slaiby, MD, Ronald Guibord, MD, Lisa J. Bergersen, BA, Patricia Nichols, DVM, Edith D. Hendley, PhD, David B. Pilcher, MD Journal of Vascular Surgery Volume 23, Issue 2, Pages 301-307 (February 1996) DOI: 10.1016/S0741-5214(96)70274-4 Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Final aortic aneurysm size (mm) in all four groups at 14 days. ANOVA, p < 0.0001. * WKY versus WKY-MAB, p < 0.001, ** WKHT versus WKHT-MAB, p < 0.001. Journal of Vascular Surgery 1996 23, 301-307DOI: (10.1016/S0741-5214(96)70274-4) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic results of representative tissue specimen (hematoxylin and eosin stain, 400×). A, Control WKY rat aorta with a marked inflammatory infiltrate, primarily composed of lymphocytes but including polymorphonuclear leukocytes and plasma cells. The normal architecture of the aortic wall is disrupted, manifested by the disorder of the smooth muscle cells and elastic fiber bundles. B, Aortic wall from a CD18 MAB-treated WKY rat shows orderly, concentric layers of smooth muscle cells and layers of elastic fibers. Inflammatory cell infiltration is absent. C, Aortic wall from this WKHT control rat shows a marked inflammatory response consistine of polymorphonuclear leukocytes and mononuclear cells. The luminal aspect of the wall demonstrates intimal hyperplasia as well as disruption and loss of internal elactic lamina. D, Aorta from a MAB-treated WKHT rat shows orderly arrangement of smooth muscle cells, a prominent internal elastic lamina, and no appreciable inflammatory infiltrate. Journal of Vascular Surgery 1996 23, 301-307DOI: (10.1016/S0741-5214(96)70274-4) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic results of representative tissue specimen (hematoxylin and eosin stain, 400×). A, Control WKY rat aorta with a marked inflammatory infiltrate, primarily composed of lymphocytes but including polymorphonuclear leukocytes and plasma cells. The normal architecture of the aortic wall is disrupted, manifested by the disorder of the smooth muscle cells and elastic fiber bundles. B, Aortic wall from a CD18 MAB-treated WKY rat shows orderly, concentric layers of smooth muscle cells and layers of elastic fibers. Inflammatory cell infiltration is absent. C, Aortic wall from this WKHT control rat shows a marked inflammatory response consistine of polymorphonuclear leukocytes and mononuclear cells. The luminal aspect of the wall demonstrates intimal hyperplasia as well as disruption and loss of internal elactic lamina. D, Aorta from a MAB-treated WKHT rat shows orderly arrangement of smooth muscle cells, a prominent internal elastic lamina, and no appreciable inflammatory infiltrate. Journal of Vascular Surgery 1996 23, 301-307DOI: (10.1016/S0741-5214(96)70274-4) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic results of representative tissue specimen (hematoxylin and eosin stain, 400×). A, Control WKY rat aorta with a marked inflammatory infiltrate, primarily composed of lymphocytes but including polymorphonuclear leukocytes and plasma cells. The normal architecture of the aortic wall is disrupted, manifested by the disorder of the smooth muscle cells and elastic fiber bundles. B, Aortic wall from a CD18 MAB-treated WKY rat shows orderly, concentric layers of smooth muscle cells and layers of elastic fibers. Inflammatory cell infiltration is absent. C, Aortic wall from this WKHT control rat shows a marked inflammatory response consistine of polymorphonuclear leukocytes and mononuclear cells. The luminal aspect of the wall demonstrates intimal hyperplasia as well as disruption and loss of internal elactic lamina. D, Aorta from a MAB-treated WKHT rat shows orderly arrangement of smooth muscle cells, a prominent internal elastic lamina, and no appreciable inflammatory infiltrate. Journal of Vascular Surgery 1996 23, 301-307DOI: (10.1016/S0741-5214(96)70274-4) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic results of representative tissue specimen (hematoxylin and eosin stain, 400×). A, Control WKY rat aorta with a marked inflammatory infiltrate, primarily composed of lymphocytes but including polymorphonuclear leukocytes and plasma cells. The normal architecture of the aortic wall is disrupted, manifested by the disorder of the smooth muscle cells and elastic fiber bundles. B, Aortic wall from a CD18 MAB-treated WKY rat shows orderly, concentric layers of smooth muscle cells and layers of elastic fibers. Inflammatory cell infiltration is absent. C, Aortic wall from this WKHT control rat shows a marked inflammatory response consistine of polymorphonuclear leukocytes and mononuclear cells. The luminal aspect of the wall demonstrates intimal hyperplasia as well as disruption and loss of internal elactic lamina. D, Aorta from a MAB-treated WKHT rat shows orderly arrangement of smooth muscle cells, a prominent internal elastic lamina, and no appreciable inflammatory infiltrate. Journal of Vascular Surgery 1996 23, 301-307DOI: (10.1016/S0741-5214(96)70274-4) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions