HAT Trick: p300, Small Molecule, Inhibitor

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HAT Trick: p300, Small Molecule, Inhibitor Melanie Ott, Eric Verdin Chemistry & Biology Volume 17, Issue 5, Pages 417-418 (May 2010) DOI: 10.1016/j.chembiol.2010.05.002 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 p300 Regulation and Its Nonhistone Substrates p300 autoacetylation enhances its acetyltransferase activity. The NAD-dependent sirtuin SIRT2 deacetylates p300 and inactivates it, while p300 acetylation of SIRT2 inhibits its deacetylase activity. Several nonhistone substrates of p300 and their possible therapeutic implications are shown. Chemistry & Biology 2010 17, 417-418DOI: (10.1016/j.chembiol.2010.05.002) Copyright © 2010 Elsevier Ltd Terms and Conditions