Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas.

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Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas aeruginosa from non-CF patients Priyanka Rao, John McCaughan, Mark McCalmont, Colin.E. Goldsmith, Valerie Hall, B. Cherie Millar, Mary-Ann McCann, Damian G. Downey, Jacqueline C. Rendall, J. Stuart Elborn, John E. Moore Journal of Cystic Fibrosis Volume 11, Issue 4, Pages 349-352 (July 2012) DOI: 10.1016/j.jcf.2012.01.002 Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Comparison of antibiotic susceptibility in eight antibiotic agents from CF-associated Pseudomonas aeruginosa and non-CF P. aeruginosa obtained from invasive blood culture material. P. aeruginosa from CF sputum (n=127 shaded bars) were compared with 123 isolates obtained from blood culture of patients without CF (unshaded bars). P. aeruginosa originating from CF sources were significantly more resistant to all classes of antibiotics tested, as well as for all individual examples of antibiotics with these classes of antibiotics. Journal of Cystic Fibrosis 2012 11, 349-352DOI: (10.1016/j.jcf.2012.01.002) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 A Venn diagram showing association between antibiotic susceptibilities of CF-associated Pseudomonas aeruginosa within three classes of antibiotics, namely aminoglycosides (tobramycin), β-lactams (meropenem) and the fluoroquinolones (ciprofloxacin). Isolates were classified as being either susceptible (complete sensitivity) or non-susceptible (moderately resistance and fully resistant). Within the Venn diagram circles are 65 isolates representing varying degrees of antibiotic resistance, whilst there are 62 isolates outside the Venn diagram, representing the susceptible isolates. Together, these constitute the entire population of P. aeruginosa isolates examined in this study (i.e. 65+62=127 isolates). Journal of Cystic Fibrosis 2012 11, 349-352DOI: (10.1016/j.jcf.2012.01.002) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Cluster analysis based on Euclidean distances relating antibiotic susceptibilities to 11 antibiotic agents amongst 127 isolates of CF-associated Pseudomonas aeruginosa. Journal of Cystic Fibrosis 2012 11, 349-352DOI: (10.1016/j.jcf.2012.01.002) Copyright © 2012 European Cystic Fibrosis Society. Terms and Conditions