Ricardo U. Sorensen, MD, Luke A. Wall, MD

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Presentation transcript:

Influenza immunization in patients with common variable immunodeficiency Ricardo U. Sorensen, MD, Luke A. Wall, MD Journal of Allergy and Clinical Immunology Volume 142, Issue 6, Pages 1759-1761 (December 2018) DOI: 10.1016/j.jaci.2018.10.013 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 The adaptive immune response to influenza. Antibodies against influenza surface antigens represent those produced by a subject after immunization/natural infection or antibodies passively transferred through IgG replacement in a patient with CVID. A, Antibodies (especially those against the H antigens) aid in the prevention of infection, whereas cytotoxic T lymphocytes (CTLs) mediate lysis of infected host cells. B, On viral antigenic drift, although antibodies might no longer recognize surface proteins, CTLs continue to play a role by recognizing conserved viral epitopes expressed by infected cells. Image art by Janin Pierce, RN. Journal of Allergy and Clinical Immunology 2018 142, 1759-1761DOI: (10.1016/j.jaci.2018.10.013) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions