The Negative BOLD Signal Unmasked

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The Negative BOLD Signal Unmasked Alex R. Wade Neuron Volume 36, Issue 6, Pages 993-995 (December 2002) DOI: 10.1016/S0896-6273(02)01138-8

Figure 1 Temporally Interleaved Measurements of BOLD Signal Level and Blood Flow All responses are above the statistical threshold shown in the central inset boxes. (A) BOLD response to a stimulus where a flickering checkerboard annulus was presented alternating with a blank gray field. Voxels are color coded according to the correlation between their BOLD signal and the presentation time course of the flickering checkerboard. (B) Cerebral blood flow measurements made in the same regions. Voxels are color coded according to the correlation between their blood flow and the stimulus. By comparing the spatial distributions in (A) and (B), it is clear that there is a strong correspondence between the CBF and the BOLD signal. Neuron 2002 36, 993-995DOI: (10.1016/S0896-6273(02)01138-8)