The Cinderella Effect: Searching for the Best Fit between Mouse Models and Human Diseases  John P. Sundberg, Derry C. Roopenian, Edison T. Liu, Paul N. Schofield  Journal of Investigative Dermatology  Volume 133, Issue 11, Pages 2509-2513 (November 2013) DOI: 10.1038/jid.2013.238 Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Human population response to injury will be highly variable, generating a normal curve. Inbred mouse strains will respond in a very limited way, corresponding closely to one human rather than as a model for the outbred population. Journal of Investigative Dermatology 2013 133, 2509-2513DOI: (10.1038/jid.2013.238) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Toll-like receptor 4 (Tlr4) is involved in endotoxin response. Single-nucleotide polymorphisms (SNPs) can have a profound effect on TLR4 function. Many inbred strains have a variety of SNPs in this gene, including ones that cause nonsynonymous coding changes (presumptive mutations, yellow boxes; http://www.sanger.ac.uk/cgi-bin/modelorgs/mousegenomes/snps). This implies that there may be major variations in response in this one assay between the strains even in a highly controlled environment. Journal of Investigative Dermatology 2013 133, 2509-2513DOI: (10.1038/jid.2013.238) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions