Blood Tfh Cells Come with Colors

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Blood Tfh Cells Come with Colors Nathalie Schmitt, Hideki Ueno Immunity Volume 39, Issue 4, Pages 629-630 (October 2013) DOI: 10.1016/j.immuni.2013.09.011 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Human Blood Tfh Subsets Studies by He et al. (2013) and Locci et al. (2013) provide insights regarding the ontogeny and functionally distinct subsets of blood Tfh cells. Human blood Tfh cell cells can be divided into four subsets according to the expression of CXCR3 and PD-1. CCR7 expression negatively correlates with PD-1 expression. The PD-1+ subsets contain cells expressing ICOS, which represent “activated” blood Tfh cells. Among the “quiescent” blood Tfh subsets, the PD-1+CXCR3− subset is the most efficient at providing help to B cells. The CXCR3+ subsets is able to provide help to B cells only when activated (ICOS+PD-1+ cells), but their ability is limited to memory B cells. Immunity 2013 39, 629-630DOI: (10.1016/j.immuni.2013.09.011) Copyright © 2013 Elsevier Inc. Terms and Conditions