Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements G.J. Despotis, MD, J.H. Joist,

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Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements G.J. Despotis, MD, J.H. Joist, MD, PhD, L.T. Goodnough, MD, S.A. Santoro, MD, PhD, E. Spitznagel, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 113, Issue 3, Pages 611-613 (March 1997) DOI: 10.1016/S0022-5223(97)70380-5 Copyright © 1997 Mosby, Inc. Terms and Conditions

Fig. 1 Bias analysis of plasma anti-Xa versus plasma-equivalent whole blood heparin concentration measurements. Heparin concentration in plasma was measured with use of an anti-Xa chromogenic assay and whole blood heparin concentration values were measured with an automated PST method with use of the Hepcon instrument. Whole blood heparin concentration values were converted to plasma equivalent values (PE) with the following formula: PE PST = (PST × 100/[100 – hematocrit]). The differences between anti-Xa and whole blood heparin concentration measurements are plotted on the y axis and the averages of the two heparin concentration values are plotted on the x axis. The mean (bias) and plus or minus two standard deviations of the differences are represented by the horizontal lines. n = 310. The Journal of Thoracic and Cardiovascular Surgery 1997 113, 611-613DOI: (10.1016/S0022-5223(97)70380-5) Copyright © 1997 Mosby, Inc. Terms and Conditions