Figure 2 Lesion localization visualized in the top view of the model Lesion localization visualized in the top view of the model In this view, the topographical distribution of lesions is shown in the anatomical grid, grouped across the 3 key regions with lateralization, replicating a distilled MRI perspective. Both T2 lesions and a representative T1 black hole are shown. (A) Top (clinical) view: water is opaque, only above-threshold peaks are visible. (B) Top (subclinical) view: water is translucent, subthreshold lesions are visible. Stephen C. Krieger et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e279 © 2016 American Academy of Neurology