Bamidele Victor Owoyele, Opeyemi Gideon Ayilara Pathophysiology

Slides:

Advertisements

Similar presentations

Organization of the Retina

Advertisements

Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease Yava L. Jones-Hall, Matthew B.

François Tremblay, Jenna Waterhouse, Janette Nason, Wilhelmina Kalt

From: Inflammatory Mediators Induced by Amyloid-Beta in the Retina and RPE In Vivo: Implications for Inflammasome Activation in Age-Related Macular Degeneration.

Quantitative analysis of retinal OCT

Volume 5, Issue 6, Pages (June 2002)

Mohan Manu T, T. Anand, Farhath Khanum Pathophysiology

Schwann cell injuries of radial nerve after lead (Pb) exposure in rats

A 43kD protein from the herb, Cajanus indicus L

Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3 Rini Varghese, Anuradha.

Figure 2 Intraretinal layer thickness measurements

Volume 11, Issue 2, Pages (October 2004)

Volume 24, Issue 4, Pages (December 2017)

Oxidative stress in autism

Volume 25, Issue 4, Pages (December 2018)

Nermien E. Waly, Abeer Refaiy, Nora M. Aborehab Pathophysiology

Volume 18, Issue 4, Pages (September 2011)

Figure 2 Optical coherence tomography of the human retina A) Detailed retinal segmentation sample on spectral-domain optical coherence tomography (OCT)

Short-term memory in mice is affected by mobile phone radiation

Optic neuritis: A mechanistic view

Activation of the Extracellular Signal-Regulated Kinase 1/2 Pathway by AAV Gene Transfer Protects Retinal Ganglion Cells in Glaucoma Yu Zhou, Vincent.

Volume 25, Issue 1, Pages (March 2018)

Volume 25, Issue 1, Pages (March 2018)

Circadian Photoreception: Spotlight on the Brain

Folic acid protects against experimental prenatal nicotine–induced cardiac injury by decreasing inflammatory changes, serum TNF and COX-2 expression

Theodore G. Drivas, Jean Bennett Neuron

Figure 1 Example OCT scan

Volume 88, Issue 3, Pages (March 2005)

A.Y Onaolapo, A.A. Adebayo, O.J Onaolapo Pathophysiology

Volume 24, Issue 1, Pages 1-8 (March 2017)

Volume 24, Issue 2, Pages (June 2017)

Evidence that obesity alters the quality of oocytes and embryos

Volume 23, Issue 4, Pages (December 2016)

Mrinal K. Sarkar, Parames C. Sil Pathophysiology

Volume 23, Issue 1, Pages (March 2016)

Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes Wale Johnson Adeyemi, Luqman Aribidesi Olayaki

Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia A. Jimoh, Y. Tanko,

Volume 22, Issue 4, Pages (December 2015)

Volume 4, Issue 6, Pages (December 2001)

Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL- 1β production and lipid peroxidation mediataed cell injury Eman.

Volume 15, Issue 1, Pages 1-8 (June 2008)

Volume 26, Issue 1, Pages (March 2019)

L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects M.O. Kehinde, S.I. Ogungbemi, C.N.

Volume 15, Issue 6, Pages (March 2005)

Kasturi Sarkar, Parames C. Sil Pathophysiology

Volume 4, Issue 5, Pages (November 2001)

Volume 19, Issue 4, Pages (September 2012)

Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3 Rini Varghese, Anuradha.

Catherine J. Hunter, Isabelle G. De Plaen Pathophysiology

Volume 3, Issue 4, Pages (April 2001)

Dietary macronutrients modulate hypertrophy and contractility of the detrusor in an experimental model of bladder obstruction Temitope G. Adedeji, Adesoji.

Volume 5, Issue 6, Pages (June 2002)

Volume 16, Issue 1, Pages (June 2009)

Peripheral brain-derived neurotrophic factor is reduced in stroke survivors with cognitive impairment Tasneem M. Hassan, Isyaku U. Yarube Pathophysiology

Volume 26, Issue 2, Pages (May 2000)

Label-Free Calcium Imaging in Ischemic Retinal Tissue by TOF-SIMS

Figure 3 Local intraclass correlation coefficients

The impact of primary and persistent cytomegalovirus infection on the progression of acute colitis in a murine model Jerry L. Brunson, Felix Becker,

Experimental maternal treatment with dexamethasone during lactation induces neonatal testicular and epididymal oxidative stress; Implications for early.

Volume 21, Issue 4, Pages (November 2014)

Increasing incidence of brain tumours in sparsely populated areas

The effect of maintenance and reversal of DOCA-Salt hypertension on extravasation of macromolecules and serum nitric oxide concentration in male rats

Volume 25, Issue 1, Pages (March 2018)

J.M.I. Malik, Z. Shevtsova, M. Bähr, S. Kügler Molecular Therapy

Retinoblastoma, an Inside Job

Encoding Light Intensity by the Cone Photoreceptor Synapse

Fig. 8. Electron micrographs taken from 8-week glaucoma retina

Fig. 7. Apoptotic cell death was evaluated via TUNEL

Mark W. Hankins, Steven Hughes Current Biology

The predicted new isoform of PCP2 is expressed in retinal ON bipolar cells. The predicted new isoform of PCP2 is expressed in retinal ON bipolar cells.

Presentation transcript:

Coconut oil protects against light-induced retina degeneration in male Wistar rats Bamidele Victor Owoyele, Opeyemi Gideon Ayilara Pathophysiology Volume 26, Issue 1, Pages 89-95 (March 2019) DOI: 10.1016/j.pathophys.2018.10.001 Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 1 Schematic representations of the experimental design. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 Effects of CNO on Caspase-3 concentration in the retina of male Wistar rats. Each value is the mean ± S.E.M. of five Wistar rats; *significantly (p < 0.05) different compared with CG, HCNO and HCNO. CG = received distilled water throughout the experiment, the histoarchitecture and cellular integrity were normal (H&E, x100). LMG = received distilled water and exposed to light. LCNO group = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. HCNO group = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 Effects of CN oil on MDA concentration in the retina of male Wistar rats. Each value is the mean ± S.E.M. of five Wistar rats; *significantly (p < 0.05) different compared with CG, HCNO and HCNO. # Significantly (p < 0.05) different compared with CG, LMG, and LCNO. CG = received distilled water throughout the experiment, the histoarchitecture and cellular integrity were normal (H&E, x100). LMG = received distilled water and exposed to light. LCNO group = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. HCNO group = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 4 Effects of CNO on GSH concentration in the retina of male Wistar rats. Each value is the mean ± S.E.M. of 5 Wistar rats; CG = received distilled water throughout the experiment. LMG = received distilled water and exposed to light. LCNO group = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. HCNO group = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 5 Effects of CNO on Catalase concentration in the retina of male Wistar rats. Each value is the mean ± S.E.M. of five Wistar rats; *significantly (p < 0.05) different compared with CG, HCNO and HCNO. CG = received distilled water throughout the experiment, the histoarchitecture and cellular integrity were normal (H&E, x100). LMG = received distilled water and exposed to light. LCNO group = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. HCNO group = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 6 Effects of CNO on TAC in the retina of male Wistar rats. Each value is the mean ± S.E.M. of five Wistar rats; *significantly (p < 0.05) different compared with CG, HCNO and HCNO. CG = received distilled water throughout the experiment., the histoarchitecture and cellular integrity were normal (H&E, x100). LMG = received distilled water and exposed to light. LCNO group = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. HCNO group = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 7 Effects of CNO on retinas of male Wistar rats. CG = received distilled water throughout the experiment. There is intact retina layer. (H&E, x100). LMG = received distilled water and were exposed to light, the retina layer was intact but the thickness was reduced. (H&E, x100). LCNO = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure, the image shows distorted retinal layers with reduced retina thickness. (H&E, x100). HCNO = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure, the image shows intact retinal layers (H&E, x100). Number of animals per group were 5, but slides are representative samples. GCL: Ganglion Cell Layer, IPL: Inner Plexiform Layer, INL: Inner Nuclear Layer, OPL: Outer Plexiform Layer, ONL: Outer Nuclear Layer, PL: Photoreceptor Layer. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 8 Effects of CNO on retina thickness of male Wistar rats. Each value is the mean ± S.E.M. of five Wistar rats; *significantly (p < 0.05) different compared with CG, HCNO and HCNO. # Significantly (p < 0.05) different compared with CG, LMG, and HCNO. CG = received distilled water throughout the experiment. received distilled water throughout the experiment, the histoarchitecture and cellular integrity were normal (H&E, x100). LMG = received distilled water and exposed to light. LCNO group = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. HCNO group = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 9 Effects of CNO on occipital cortex of male Wistar rats. CG = received distilled water throughout the experiment, the histoarchitecture and cellular integrity were normal (H&E, x100). LMG = received distilled water and exposed to light, has occipital cortex with perineural vacoulation (PV). (H&E, x100). LCNO = received 5 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure, has occipital cortex with perineural vacoulation (PV). (H&E, x100). HCNO = received 10 ml/kg of CN oil for 14 days prior to light exposure and 7 days after light exposure, has occipital cortex with perineural vacoulation (PV). (H&E, x100). Number of animals per group were five, but slides are representative samples. Pathophysiology 2019 26, 89-95DOI: (10.1016/j.pathophys.2018.10.001) Copyright © 2018 Elsevier B.V. Terms and Conditions