Bioactive Peptides from Libraries

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Presentation transcript:

Bioactive Peptides from Libraries Chiara Falciani, Luisa Lozzi, Alessandro Pini, Luisa Bracci Chemistry & Biology Volume 12, Issue 4, Pages 417-426 (April 2005) DOI: 10.1016/j.chembiol.2005.02.009 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Portion Mixing Method for Synthetic Combinatorial Libraries The resin is divided and recombined at every coupling step. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 Descriptive Model of Iterative Process and Positional Scanning Deconvolution Approaches See text for details. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 3 Dynamic Libraries See text for details. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 4 Example of Libraries from Libraries See text for details. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 5 Peptides Displayed on M13 Phage Surface as Fusion to the Amino Terminus of pVIII (A) or pIII (B) Coat Proteins Proportions are not observed in this picture. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 6 Examples of Constrained Structures See text for details. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 7 Schematic Representation of the Similarity of MAP to Phage Displayed (A) and Membrane Bound (B) Peptides See text for details. Chemistry & Biology 2005 12, 417-426DOI: (10.1016/j.chembiol.2005.02.009) Copyright © 2005 Elsevier Ltd Terms and Conditions