Berta Almoguera, PhD, Lyam Vazquez, MD, Frank Mentch, PhD, Michael E

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Presentation transcript:

Novel locus for atopic dermatitis in African Americans and replication in European Americans Berta Almoguera, PhD, Lyam Vazquez, MD, Frank Mentch, PhD, Michael E. March, PhD, John J. Connolly, PhD, Peggy L. Peissig, PhD, James G. Linneman, BA, María del Carmen Plaza-Serón, PhD, Maria Pino-Yanes, PhD, Esteban G. Burchard, MD, Murray Brilliant, PhD, Patrick Sleiman, PhD, Hakon Hakonarson, MD, PhD Journal of Allergy and Clinical Immunology Volume 143, Issue 3, Pages 1229-1231 (March 2019) DOI: 10.1016/j.jaci.2018.10.038 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Regional association plot at the chromosome 1 locus in AD following meta-analysis in AAs. Statistical significance of each SNP plotted on the y-axis as a function of chromosome position on the x-axis. The top SNP at the locus, rs3811419, is shown in purple, the strength LD (r2) of surrounding SNPs with the top SNP is indicated by the colored dots, and the scale is presented in the legend. Gray represents unknown r2. The fine scale recombination rate is shown on the right side of the plots in blue. Journal of Allergy and Clinical Immunology 2019 143, 1229-1231DOI: (10.1016/j.jaci.2018.10.038) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions