Mice with neutrophil-specific deletion of IFNLR1 or STAT1 succumb to IA. Mice with neutrophil-specific deletion of IFNLR1 or STAT1 succumb to IA. Conditional.

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Mice with neutrophil-specific deletion of IFNLR1 or STAT1 succumb to IA. Mice with neutrophil-specific deletion of IFNLR1 or STAT1 succumb to IA. Conditional gene targeting in neutrophils was achieved by crossing Ifnlr1fl/fl and Stat1fl/fl mice with MRP8cre. Gene-targeted animals and control mice were infected with 8 × 107 CEA10 Af conidia. Control groups were WT B6 mice, Ifnlr1fl/fl, Stat1fl/fl, and MRP8cre. (A) Kaplan-Meier survival plot for 10 mice per group analyzed in two independent experiments. (B) Representative images of Gomori ammoniacal silver–stained lung sections captured at ×40 magnification. (C) Neutrophil recruitment to the lung of infected mice at 48 hours after infection with 4 × 107 CEA10 Af conidia. Each symbol represents one mouse. Data are cumulative of two independent experiments. (D) Pulmonary levels of TNF as measured by ELISA. (E and F) ROS generation by airway-infiltrating neutrophils (E) and pulmonary fungal burden (F) 48 hours after Af infection. Each symbol represents one mouse. Data shown are cumulative of two independent experiments. Statistical analysis was done with Kruskal-Wallis nonparametric test for multiple comparisons using Prism software. **P < 0.01; ***P < 0.001 for each labeled sample as compared with WT mice. Vanessa Espinosa et al. Sci. Immunol. 2017;2:eaan5357 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works