Volume 146, Issue 3, Pages 622-629.e4 (March 2014) The Clinical Consequences of Advanced Imaging Techniques in Barrett's Esophagus  David F. Boerwinkel, Anne-Fré Swager, Wouter L. Curvers, Jacques J.G.H.M. Bergman  Gastroenterology  Volume 146, Issue 3, Pages 622-629.e4 (March 2014) DOI: 10.1053/j.gastro.2014.01.007 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 (A) Examples of subtle neoplastic lesions in BE. (B) The neoplastic lesions are indicated with circles. Reproduced with permission from www.endosurgery.eu. Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 Overview and detailed images of neoplastic lesions in BE. (A and C) Olympus high-resolution WLE and (B and D) NBI, (E and G) Fujinon WLE and (F and H) BLI, (I and K) Fujinon WLE and (J and L) Fuji Intelligent Chromo Endoscopy, and (M and O) Pentax WLE and (N and P) i-scan. Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Overview, detailed, and near-focus images of a neoplastic lesion in BE with (A, C, and E) WLE and (B, D, and F) NBI. The red lines indicate the border of the vascular and mucosal abnormalities based on the NBI appearance, and the blue lines illustrate the extension of the neoplastic lesion based on the mucosal relief, which can be better appreciated with NBI compared with WLE. Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 Image of an early neoplastic lesion in the distal esophagus (A) with high-resolution WLE, (B) with NBI, (C) after indigo carmine spraying, and (D) after acetic acid spraying. Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 Three examples of neoplastic lesions in BE with (A, C, and E) WLE and (B, D, and F) AFI. In C and D, the lesion is hard to detect with WLE but can be clearly appreciated with AFI. In E and F, the lesion is located at the gastric folds, which makes the interpretation of AFI difficult, resulting in high false-positive rates for AFI. Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 3 Images of an early neoplastic lesion in BE that is difficult to appreciate when the esophagus is fully inflated. (A and B) By alternating inflation and suction, the lesion becomes more apparent. (C and D) By looking in retroflex, lesions at the distal esophagus may be detected that would have been missed when only antegrade inspection would have been performed. Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 4 NBI not only facilitates the evaluation of the mucosal and vascular patterns but also enhances visualization of the mucosal relief, a distinct and recognizable feature of NBI (C, F, J, and K). Although the mucosal and vascular patterns may be regular, the relief can be used to assess the extension of the lesion to direct the delineation (G) before endoscopic resection (D, H, and L). Gastroenterology 2014 146, 622-629.e4DOI: (10.1053/j.gastro.2014.01.007) Copyright © 2014 AGA Institute Terms and Conditions