Recipient intramuscular gene transfer of active transforming growth factor-β1 attenuates acute lung rejection Takashi Suda, MD, Franco D’Ovidio, MD,

Slides:

Advertisements

Similar presentations

Cardiac “Fitness” Training: An Experimental Comparative Study of Three Methods of Pulmonary Artery Banding for Ventricular Training Emmanuel Le Bret,

Advertisements

Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I

A Scimitar Syndrome Variant: Anomalous Systemic Arterial Supply to the Right Lung With Normal Pulmonary Venous Return Luis Gorospe, MD, Amparo Esteban-Peris,

Postoperative Atrial Fibrillation Prophylaxis After Lung Surgery: Systematic Review and Meta-Analysis Lars Peter Riber, MD, PhD, Torben Bjerregaard Larsen,

Bing-Yen Wang, MD, Hsiao-Huang Chang, MD, PhD, I

Gene transfer of heat shock protein 70 protects lung grafts from ischemia-reperfusion injury Masafumi Hiratsuka, MD, Bassem N Mora, MD, Motoki Yano,

Robert J Cerfolio, MD, Cyndi Bass, MSN, Charles R Katholi, PhD

Thoracoscopic resection of an ectopic intrathoracic goiter

Burdens Without Blessings: Peer Reviewers Get No Respect

Anomalous Great Cardiac Vein Draining Into the Superior Vena Cava

Michelle C. Ellis, MD, Brian S. Diggs, PhD, John T. Vetto, MD, Paul H

Prox-1: A Specific and Sensitive Marker for Lymphatic Endothelium in Normal and Diseased Human Tissues Eumenia Costa da Cunha Castro, MD, PhD, Csaba.

Total Liquid Ventilation Reduces Lung Injury in Piglets After Cardiopulmonary Bypass Lijun Jiang, MD, Qiang Wang, MD, Yinglong Liu, MD, Ming Du, MD, Xiangdong.

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Pleural Metastasis of Osteosarcoma

Public policy and the practicing physician

Total Arterial Revascularization: A Superior Strategy for Diabetic Patients Who Require Coronary Surgery James Tatoulis, MD, FRACS, Rochelle Wynne, PhD,

Who Do You Say You Are? The Annals of Thoracic Surgery

Cardiogenic shock due to coronary narrowings one day after a MAZE III procedure Eric Berreklouw, MD, PhD, Frank Bracke, MD, Albert Meijer, MD, PhD, Kathinka.

Use of Amiodarone After Major Lung Resection

Thomas Bruce Ferguson, MD, May 6, 1923–May 26, 2013

Role of Airway Epithelial Injury in Murine Orthotopic Tracheal Allograft Rejection Elbert Kuo, MD, Ankit Bharat, MD, Jennifer Shih, BS, Tyler Street,

Anomalous Origin of Left Pulmonary Artery From Left Subclavian Artery

Sternal Closure With Tie Bands: A Word of Caution

Tsutomu Tagawa, MDa, Takashi Suda, MDa, Niccolò Daddi, MDa, Benjamin D

Invasive Desmoplastic Fibroblastoma in the Chest Wall

Eric S. Weiss, MD, MPH, Jeremiah G. Allen, MD, Christian A

Percutaneous Transcatheter Closure of the Aortic Valve

The Utility of Electromagnetic Navigational Bronchoscopy as a Localization Tool for Robotic Resection of Small Pulmonary Nodules William D. Bolton, MD,

Adenovirus encoding soluble tumor necrosis factor α receptor immunoglobulin prolongs gene expression of a cotransfected reporter gene in rat lung Takashi.

Michael H. Cho, MD, Atul Malhotra, MD, Dean M. Donahue, MD, John C

Samer A. Kanaan, MD, Benjamin D

Efficient naked plasmid cotransfection of lung grafts by extended lung/plasmid exposure time Franco D’Ovidio, MD, Niccolò Daddi, MD, Takashi Suda, MD,

Bradford B. Smith, MD, Matthew A

Sarah C. Huen, MD, Chirag R. Parikh, MD, PhD

Mitral Valve Necrosis After Cardiac Surgery Using Gelatin-Resorcinol-Formaldehyde Glue Yuki Tanaka, MD, Tadashi Kitamura, MD, PhD, Yurie Miyata, MD,

Severe Two-Vessel Ostial Stenosis of the Main Coronary Arteries in a Patient With Transposition of the Great Arteries After an Arterial Switch Operation

Ex vivo transfection of pulmonary artery segments in lung isografts

Completely Thrombosed Tricuspid Pouch Mimicking a Cardiac Tumor

Thoracoscopic Bleb Resection Using Two-Lung Ventilation Anesthesia With Low Tidal Volume for Primary Spontaneous Pneumothorax Heezoo Kim, MD, PhD, Hyun.

An Unusual Cause of Hemoptysis in a Young Woman

Vacuum-Assisted Closure for the Treatment of Complex Chest Wounds

The Annals of Thoracic Surgery

The Annals of Thoracic Surgery

Pulmonary Valve Replacement for Pacing Electrodes Related Bacterial Endocarditis Vilém Rohn, MD, PhD, Marek Šlais, MD, Tomáš Kotulák, MD, Michal Pšenička,

Acute Esophageal Necrosis: A Case Series and Long-Term Follow-Up

Bassem N Mora, MD, Carlos H

Endobronchial transfection of naked TGF-β1 cDNA attenuates acute lung rejection Franco D’Ovidio, MD, Motoki Yano, MD, Jon H Ritter, MD, Thalachallour.

First Report on 30-day and Operative Mortality in Risk Model of Isolated Coronary Artery Bypass Grafting in Japan Noboru Motomura, MD, PhD, Hiroaki Miyata,

Dana Y. Fuhrman, DO, MS, Lan G

Invited Commentary The Annals of Thoracic Surgery

Robert Lee Replogle, September 30, 1931–May 9, 2016

Tricuspid Valve Repair of Idiopathic Papillary Muscle Rupture

Antibodies to Self-Antigens Predispose to Primary Lung Allograft Dysfunction and Chronic Rejection Ankit Bharat, MD, Deepti Saini, PhD, Nancy Steward,

K. Eric Sommers, MD, Bartley P. Griffith, MD, Robert L

The American Board of Thoracic Surgery: Update

Neal S Goldstein, MD The Annals of Thoracic Surgery

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

Lung Retransplantation for Chronic Rejection: A Single-Center Experience Sreeja Biswas Roy, MBBS, Roshan Panchanathan, BS, Rajat Walia, MD, Katherine.

Increased Rehospitalization Rate After Coronary Bypass Operation for Acute Coronary Syndrome: A Prospective Study in 200 Patients Staffan Bjessmo, MD,

Development of abnormal tissue architecture in transplanted neonatal rat myocytes Peter Whittaker, PhD, Jochen Müller-Ehmsen, MD, Joan S Dow, BS, Larry.

Hideki Itano, MDa, Bassem N. Mora, MDa, Wanjiang Zhang, MDa, Jon H

Dumbor L. Ngaage, MD, FRCS (C-Th), Michael E. Cowen, FRCS

Mark I. Block, MD The Annals of Thoracic Surgery

Late Consequences of a Much Earlier Decision

The Impact of New Technology on Cardiothoracic Surgical Practice

Domenico Galetta, MD, PhD, Lorenzo Spaggiari, MD, PhD

Harvey Edward Garrett, MD, Bradley A. Wolf, MD

J. Alberto Lopez, MD The Annals of Thoracic Surgery

David S. Mulder, MD The Annals of Thoracic Surgery

Presentation transcript:

Recipient intramuscular gene transfer of active transforming growth factor-β1 attenuates acute lung rejection Takashi Suda, MD, Franco D’Ovidio, MD, Niccolo Daddi, MD, Jon H Ritter, MD, Thalachallour Mohanakumar, PhD, G.Alexander Patterson, MD The Annals of Thoracic Surgery Volume 71, Issue 5, Pages 1651-1656 (May 2001) DOI: 10.1016/S0003-4975(01)02528-0 Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Level of active TGF-β1 in muscle (A) and plasma (B) of rats injected with AdCMVTGFβ1, AdCMVβgal, or normal saline. Muscles were collected at various time points after injection, and were assayed by ELISA. ∗p < 0.05, ∗∗p < 0.005. The Annals of Thoracic Surgery 2001 71, 1651-1656DOI: (10.1016/S0003-4975(01)02528-0) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 The mean arterial oxygenation (PaO2) after mono-ventilation of the allograft at the time of sacrifice on the fifth postoperative day. PaO2 in group I was superior in comparison with group II and group III. ∗p < 0.05, ∗∗p < 0.005. The Annals of Thoracic Surgery 2001 71, 1651-1656DOI: (10.1016/S0003-4975(01)02528-0) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 H-E staining (A) and Collagen red and Elastin black EVG staining (B) in muscle with transfected active TGF-β1. (A) There is some focal myocyte necrosis, while other myofibers are trapped within and compressed by granulation tissue with fibroblast accumulation (×100). (B) The EVG-stained section of the AdCMVTGFβ1 injected highlights the areas of myocyte destruction, and also indicates the cellular nature of the fibrosis, with accumulation of fibroblasts and only modest collagen deposition. Increased elastin was not clear (×100). The Annals of Thoracic Surgery 2001 71, 1651-1656DOI: (10.1016/S0003-4975(01)02528-0) Copyright © 2001 The Society of Thoracic Surgeons Terms and Conditions