Outcomes of multistage palliation of infants with functional single ventricle and heterotaxy syndrome Bahaaldin Alsoufi, MD, Courtney McCracken, PhD,

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Outcomes of multistage palliation of infants with functional single ventricle and heterotaxy syndrome Bahaaldin Alsoufi, MD, Courtney McCracken, PhD, Brian Schlosser, BS, RDCS, Ritu Sachdeva, MBBS, Andrew Well, PhD, Brian Kogon, MD, William Border, MBChB, MPH, Kirk Kanter, MD The Journal of Thoracic and Cardiovascular Surgery Volume 151, Issue 5, Pages 1369-1377.e2 (May 2016) DOI: 10.1016/j.jtcvs.2016.01.054 Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Competing risks analysis of outcomes after first-stage palliation surgery in 58 neonates with heterotaxy syndrome. The solid lines represent parametric point estimates, and the dashed lines enclose the 95% confidence interval. A, Competing hazard functions for each outcome. B, Proportion of neonates in each of the categories at any given time after first-stage surgery. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Parametric model for survival following initial palliation surgery in 67 infants with heterotaxy syndrome, stratified by the need for concomitant TAPVC repair. TAPVC, Total anomalous pulmonary venous connection. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Competing risks analysis depiction of events following first-stage palliation in (A) neonates with heterotaxy syndrome and (B) a matched control group of neonates without heterotaxy syndrome with other forms of single ventricle anomalies. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Time-dependent survival and risk hazard of death over time following first-stage palliation in neonates with heterotaxy syndrome and a matched control group of neonates without heterotaxy syndrome with other forms of single ventricle anomalies. SV, Single ventricle; HTX, heterotaxy syndrome. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 A, Proportion of patients without the Fontan operation and (B) hazard for the Fontan operation over time following the Glenn procedure in 49 infants with heterotaxy syndrome. The solid lines represent parametric point estimates, and the dashed lines enclose the 95% confidence interval. In A, the circles represent nonparametric estimates. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 A, Time-dependent survival and (B) risk hazard of death over time following initial palliation surgery in 67 infants with heterotaxy syndrome. The solid lines in the parametric model represent parametric point estimates, and the dashed lines enclose the 95% confidence interval. In A, the circles represent nonparametric estimates. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions

Competing events following palliation for heterotaxy syndrome versus nonheterotaxy syndrome single ventricle. The Journal of Thoracic and Cardiovascular Surgery 2016 151, 1369-1377.e2DOI: (10.1016/j.jtcvs.2016.01.054) Copyright © 2016 The American Association for Thoracic Surgery Terms and Conditions