Volume 67, Issue 6, Pages (June 2005)

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Volume 67, Issue 6, Pages 2383-2392 (June 2005) Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin Peter Stenvinkel, Kai Wang, Abdul Rashid Qureshi, Jonas Axelsson, Roberto Pecoits-Filho, Ping Gao, Peter Barany, Bengt Lindholm, Tomas Jogestrand, Olof Heimberger, Clifford Holmes, Martin Schalling, Louise Nordfors Kidney International Volume 67, Issue 6, Pages 2383-2392 (June 2005) DOI: 10.1111/j.1523-1755.2005.00345.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Box plots showing serum albumin (A) and fetuin-A (B) levels in 101 ESRD patients with and without carotid plaques. Kidney International 2005 67, 2383-2392DOI: (10.1111/j.1523-1755.2005.00345.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 The correlation (Rho = 0.30;P < 0.0001) between fetuin-A and serum albumin in 258 ESRD patients. Kidney International 2005 67, 2383-2392DOI: (10.1111/j.1523-1755.2005.00345.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Kaplan-Meier curves showing differences in all-cause (log-rank 34.2;P < 0.0001) (A) and cardiovascular (log-rank 23.4;P < 0.0001) (B) mortality in 258 ESRD patients starting renal replacement therapy according to basal serum fetuin-A levels (quartiles). Kidney International 2005 67, 2383-2392DOI: (10.1111/j.1523-1755.2005.00345.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Kaplan-Meier curves showing unadjusted (log-rank 19.6;P < 0.0001) (A) and adjusted (likelihood ratio 118.1P < 0.0001) all-cause mortality (B) in 258 ESRD patients according to median fetuin-A levels. Kidney International 2005 67, 2383-2392DOI: (10.1111/j.1523-1755.2005.00345.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 5 Box plot showing serum fetuin-A levels in 215 ESRD patients according to the AHSG Thr256Ser polymorphism and evidence of inflammation (CRP ≥10 mg/L). Kidney International 2005 67, 2383-2392DOI: (10.1111/j.1523-1755.2005.00345.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 6 Kaplan-Meier curve showing differences (log-rank 27.6,P < 0.0001) in all-cause mortality in ESRD patients divided into four groups according to the presence (CRP ≥10 mg/L) or absence of inflammation and the presence or absence of the amino acid serine at position 256. Kidney International 2005 67, 2383-2392DOI: (10.1111/j.1523-1755.2005.00345.x) Copyright © 2005 International Society of Nephrology Terms and Conditions