Depth of Submucosal Invasion Does Not Predict Lymph Node Metastasis and Survival of Patients With Esophageal Carcinoma  Rami J. Badreddine, Ganapathy A. Prasad, Jason T. Lewis, Lori S. Lutzke, Lynn S. Borkenhagen, Kelly T. Dunagan, Kenneth K. Wang  Clinical Gastroenterology and Hepatology  Volume 8, Issue 3, Pages 248-253 (March 2010) DOI: 10.1016/j.cgh.2009.11.016 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Overall unadjusted survival of patients with sm1 submucosal esophageal adenocarcinoma and sm2/sm3 submucosal esophageal adenocarcinoma (P = .43). Black indicates sm1, gray sm2/sm3. Clinical Gastroenterology and Hepatology 2010 8, 248-253DOI: (10.1016/j.cgh.2009.11.016) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Cancer-free survival of patients with sm1 submucosal esophageal adenocarcinoma and sm2/sm3 submucosal esophageal adenocarcinoma (P = .48). Black indicates sm1, gray sm2/sm3. Clinical Gastroenterology and Hepatology 2010 8, 248-253DOI: (10.1016/j.cgh.2009.11.016) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1A (A) SM1-High power view. Infiltrating malignant glands extend just through the muscularis mucosae into the loose connective tissue of the submucosa. (B) SM2-Low power view. Tumor extends into the middle third of the submucosa. The thick bundles of smooth muscle which compose the muscularis propria are seen at the bottom of the field. (C) SM3-Low power. Invasive adenocarcinoma abuts but does not invade the muscularis propria. (D) Lymph node involved by metastatic adenocarcinoma from an SM3 case. Clinical Gastroenterology and Hepatology 2010 8, 248-253DOI: (10.1016/j.cgh.2009.11.016) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1B Clinical Gastroenterology and Hepatology 2010 8, 248-253DOI: (10.1016/j.cgh.2009.11.016) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1C Clinical Gastroenterology and Hepatology 2010 8, 248-253DOI: (10.1016/j.cgh.2009.11.016) Copyright © 2010 AGA Institute Terms and Conditions

Supplementary Figure 1D Clinical Gastroenterology and Hepatology 2010 8, 248-253DOI: (10.1016/j.cgh.2009.11.016) Copyright © 2010 AGA Institute Terms and Conditions