Lane J. Brunner, William M. Bennett, Dennis R. Koop

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Presentation transcript:

Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner Lane J. Brunner, William M. Bennett, Dennis R. Koop Kidney International Volume 54, Issue 1, Pages 216-223 (July 1998) DOI: 10.1046/j.1523-1755.1998.00970.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Markers of renal function in rats following treatment with either cyclosporine (•) or vehicle (○) as outlined in the Methods section. Abbreviations are: SCr, serum creatinine; CCr, creatinine clearance; FEK, fractional excretion of potassium; UOsm, urine osmolality. Data are expressed as mean ± standard error of four rats in each group. Kidney International 1998 54, 216-223DOI: (10.1046/j.1523-1755.1998.00970.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Hepatic microsomal P450 3A2 and 2C11 protein levels and P450-dependent testosterone hydroxylation produced by rats following treatment with either cyclosporine (•) or vehicle (○) as outlined in the Methods section. Microsomal protein band density is indicated in arbitrary units. 6β-OHT and 2α-OHT represent the in vitro microsomal production of 6β-hydroxytestosterone and 2α-hydroxytestosterone, respectively. Catalytic activity is expressed as nmol product/min/mg protein. Data are expressed as mean ± standard error of four rats in each group. Kidney International 1998 54, 216-223DOI: (10.1046/j.1523-1755.1998.00970.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Steroid 5α-reductase activity in the production of androstanedione by hepatic microsomes from rats following treatment with either cyclosporine (•) or vehicle (○) as outlined in the Methods section. Catalytic activity is expressed as nmol product/min/mg protein. Data are expressed as mean ± standard error of four rats in each group. Kidney International 1998 54, 216-223DOI: (10.1046/j.1523-1755.1998.00970.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Whole blood cyclosporine trough levels in rats administered cyclosporine 15mg/kg/day by subcutaneous injection for up to 28days and then following drug discontinuation for an additional 15days. Data are expressed as mean ± standard error of four rats in each group. Kidney International 1998 54, 216-223DOI: (10.1046/j.1523-1755.1998.00970.x) Copyright © 1998 International Society of Nephrology Terms and Conditions