Gene expression changes evoked in a venous segment exposed to arterial flow Deborah Abeles, MD, Stephanie Kwei, MD, George Stavrakis, MS, Yuzhi Zhang,

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Gene expression changes evoked in a venous segment exposed to arterial flow Deborah Abeles, MD, Stephanie Kwei, MD, George Stavrakis, MS, Yuzhi Zhang, MS, Eric T. Wang, AB, Guillermo García-Cardeña, PhD Journal of Vascular Surgery Volume 44, Issue 4, Pages 863-870 (October 2006) DOI: 10.1016/j.jvs.2006.05.043 Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 1 Differential gene expression in remodeled versus control external jugular veins. Up-regulated genes are visualized as shades of red, corresponding to P < .05, above the unity line. Down-regulated genes are visualized as shades of blue below the unity line. Journal of Vascular Surgery 2006 44, 863-870DOI: (10.1016/j.jvs.2006.05.043) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 2 Morphological changes in the vessel wall visualized by Movat’s pentachrome stain. (A) Sham operated carotid artery. (B) Contralateral control external jugular vein. (C) Remodeled vein on day 1. (D) Remodeled vein on day 3. (E) Remodeled vein on day 5. (F) Remodeled on day 7. Inset in right lower corner: note the wisps of elastin in black, magnification: 1000x. The lumen of the vessel, indicated as L, is at the top of all images. Magnification: 400x. Scale bar: 50 microns. (G) Total wall thickness measured in microns. Journal of Vascular Surgery 2006 44, 863-870DOI: (10.1016/j.jvs.2006.05.043) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 3 Immunohistochemistry of the remodeled vein. EJV = external jugular vein. Tn-C = tenascin-c. TSP = thrombospondin. The arrows in (I) and (J) indicate thrombospondin expression in inflammatory cells. LO = lysyl oxidase. The arrow in (O) indicates lysyl oxidase expression in inflammatory cells. OPN = osteopontin. The arrowhead and arrow in (U) indicates osteopontin expression in endothelial cells and inflammatory cells respectively. The lumen of the vessel, indicated as L, is at the top of all images. Magnification: 400x. Scale bar: 50 microns. Journal of Vascular Surgery 2006 44, 863-870DOI: (10.1016/j.jvs.2006.05.043) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions